CREM mutations and ADHD symptoms

Medical Hypotheses
Tuuli A Lahti, Timo Partonen

Abstract

CREM mutant mice have behaviors similar to symptoms seen in ADHD such as the increased level of physical activity as well as altered emotional and stress responses. Our results demonstrate that all the four participants with ADHD had elevated levels of nocturnal melatonin in urine samples before starting the methylphenidate treatment. We hypothesize that abnormalities in CREM protein functions or mutations in the CREM gene may be underlying at least some of the symptoms in patients with ADHD.

References

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Citations

Oct 24, 2012·Journal of Psychiatric Research·Antonio Molina-CarballoAntonio Muñoz-Hoyos
Mar 26, 2013·International Journal of Molecular Medicine·Hideyuki YamamotoHiromichi Yamanishi
Jun 21, 2020·Translational Psychiatry·Paula RoviraMarta Ribasés

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