PMID: 9544932Apr 17, 1998Paper

Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp

The Journal of Antibiotics
M IgarashiM Ishizuka

Abstract

A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.

Citations

Oct 16, 2018·Frontiers in Microbiology·Hefa Mangzira KemungLearn-Han Lee
Jun 14, 2014·Natural Product Reports·Fumitaka KudoTadashi Eguchi
Mar 20, 2015·Chembiochem : a European Journal of Chemical Biology·Fumitaka KudoTadashi Eguchi
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson

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