Crescentic glomerulonephritis due to rifampin treatment in a patient with pulmonary atypical mycobacteriosis

Nephron
H OgataM Fujishima

Abstract

A 64-year-old male was treated continuously with rifampin, isoniazid and streptomycin for pulmonary atypical mycobacteriosis, Mycobacterium kansasii. Five weeks after beginning the treatment, the patient suddenly developed acute renal failure. A renal biopsy showed crescentic lesions characteristic of rapidly progressive glomerulonephritis with moderate interstitial changes. Serum antirifampin antibody was detected, and the cessation of rifampin treatment was followed by a rapid spontaneous recovery of the patient's renal function. This is, to our knowledge, the first case of rapidly progressive crescentic glomerulonephritis associated with rifampin treatment where circulating antirifampin antibody is demonstrated and the renal function spontaneously improved after discontinuing rifampin treatment.

Citations

Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K KohnoS Okuda
Dec 24, 2005·Expert Opinion on Drug Safety·Hassan IzzedineGilbert Deray
Mar 1, 2006·Expert Opinion on Drug Safety·Eric J Forget, Dick Menzies
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thangamani MuthukumarMuthayeepalayam A Muthusethupathi
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Feb 14, 2018·BMJ Case Reports·Jonathan Oxley OxlandRobert Freercks
Jul 15, 2021·CEN Case Reports·Paul TorpianoDavid Pace

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