Crescents and Global Glomerulosclerosis in Chinese IgA Nephropathy Patients: A Five-Year Follow-Up

Kidney & Blood Pressure Research
Wei PengWei Qin

Abstract

This study aims to evaluate the clinical significance of crescent and global glomerulosclerosis formation on renal outcome in patients with IgA nephropathy (IgAN). Biopsy-proven primary IgAN patients from West China Hospital of Sichuan University were studied retrospectively between 2008 and 2015. Clinicopathological features and treatment modalities were recorded. The patients were divided into several groups on the basis of cellular and/or fibrocellular crescents scores and global glomerulosclerosis scores. Crescent (C) was scored according to the updated Oxford classification (C0/C1/C2). Global glomerulosclerosis (G) was scored according to the frequency of global glomerulosclerosis: G0 (≤25% of glomeruli), G1 (26-50% of glomeruli), and G2 (> 50% of glomeruli). The primary endpoint was defined as a 50% reduction in renal function or end stage renal disease. Patients were followed up for at least 12 months, or shorter if they reached study endpoints. 1328 patients with IgAN were recruited. Mean follow-up time was 46.1±23.6 months. The percentage of patients with C1 and C2 was 19.3% and 5.9% respectively. Higher crescent scores was associated with lower estimated glomerular filtration rates (eGFR), decreased serum albumin leve...Continue Reading

Citations

Mar 7, 2020·Current Opinion in Nephrology and Hypertension·Lidia AnguianoHans-Joachim Anders
Sep 19, 2020·International Urology and Nephrology·Dongmei WenWei Qin
Aug 11, 2020·Kidney Research and Clinical Practice·Ji-Hye LeeSamel Park
Apr 28, 2021·International Urology and Nephrology·Xinyao LuoYahong Hu
Apr 17, 2020·Kidney & Blood Pressure Research·Precil Diego Miranda de Menezes NevesViktoria Woronik

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