PMID: 7017449May 1, 1981Paper

Creutzfeldt-Jacob disease: a golgi study

Neuropathology and Applied Neurobiology
Isidro FerrerJ M Grau Veciana

Abstract

A cerebral biopsy of a patient with Creutzfeldt-Jacob (C-J) disease was examined with the Golgi method. Distortion of soma and neuronal processes associated with vacuolization of the neuropil was observed. The main findings were decreased numbers of basal dendrites and of branches of the apical dendrite of the pyramidal cells, marked loss of synaptic spines, and varicosities in the proximal segment of some apical and basal dendrites. These changes, though non-specific, may be interpreted as the result of deafferentation, although primary reactions related to C-J disease cannot be ruled out. These changes underline the intense disruption of intracortical connections which takes place in this condition in addition to the neuronal loss.

References

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Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J BercianoM Lafarga
Jan 1, 1989·Journal of the Neurological Sciences·J H Kim, E E Manuelidis
Jun 28, 2002·Brain Research. Brain Research Reviews·John C FialaKristen M Harris
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I L CampbellL Mucke
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ChavanyM Jendoubi
Dec 1, 1993·Annals of Neurology·I FerrerR Rivera
Jan 1, 1983·Acta Neuropathologica·I FerrerJ M Grau Veciana
Nov 21, 2017·Journal of Alzheimer's Disease : JAD·Isidro Ferrer

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