Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings

Arquivos de neuro-psiquiatria
Walter Oleschko ArrudaRicardo Ramina

Abstract

Creutzfeldt-Jakob disease (CJD) is a presenile dementia characterized by rapidly progressive mental deterioration, myoclonic jerking, and other less common neurological signs. Few autoctonous cases have been described in Brazil. A 54-year-old white woman, was admitted in our service with a month history of progressive, bilateral cortical blindness. After admission, she developed right partial motor seizures( right facial, upper and lower limbs), she became progressively aphasic( mixed aphasia). Seizures were controlled with phenytoin, but she developed choreoathetotic movements on her right dimidium, with partial control after introduction of chlorpromazine 25 mg q/d. She could no longer stand up or walk due to severe ataxia. The first EEG (October, 2001) showed left hemisphere severe seizure activity (status epilepticus partialis). She was delivered home with enteral nutrition, phenytoin, chlorpromazine and mepacrine 100 mg qd. The following laboratorial tests were negative or normal: blood series, platelets, ESR, kidney and liver function, copper, ceruloplasmin, VDRL, HIV, HTLV-1, lactate, and cerebral DSA (performed in other service).A spinal tap with normal opening pressure was perform and CSF examination was normal. CSF 14...Continue Reading

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Citations

Aug 13, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jason R CorneliusNeeraj Kumar
Nov 26, 2010·Expert Opinion on Pharmacotherapy·Brian S Appleby, Constantine G Lyketsos
Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I Zerr, T A Polyakova

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