Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?

Brain, Behavior, and Immunity
Michael J YoungJeremy D Schmahmann

Abstract

We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease. This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. The global prevalence of both COVID-19 and neurodegenerative disorders adds urgency to the study of this potential relationship.

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Citations

Oct 8, 2020·International Journal of Molecular Sciences·Neil A MabbottDavid S Donaldson
Jan 24, 2021·BMJ Supportive & Palliative Care·Kay De VriesKaren Harrison Dening
Jan 5, 2021·Oxford Medical Case Reports·Christopher E McMurranSolomon O Ugoya
Mar 9, 2021·Frontiers in Physiology·Geoffroy VellieuxMarie-Pia d'Ortho
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Apr 27, 2021·Frontiers in Aging Neuroscience·Chao HuXiao-Ping Dong
May 4, 2021·Frontiers in Public Health·Sanjana Fatema ChowdhurySaeed Anwar
Jul 17, 2021·Clinical Case Reports·Mehri Salari, Masoud Etemadifar

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Methods Mentioned

BETA
PCR

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