Creutzfeldt-Jakob disease with unusually extensive neuropathology in a child treated with native human growth hormone.

Clinical Neuropathology
Jacqueline MikolFrançoise Goutieres

Abstract

We report a case of iatrogenic Creutzfeldt-Jakob disease(iCJD) in a child with a neonatal growth hormone (GH) deficiency that was treated with native human growth hormone (hGH) between the ages of 9 months and 7 years. Three years after the end of treatment a progressive neurological syndrome consistent with Creutzfeldt-Jakob disease (CJD) developed, leading to death within a year, at age 11. Neuropathological examination showed an unusual widespread form of CJD, notably characterized by (i) involvement of the cerebellar white matter, (ii) cortico-spinal degeneration and (iii) ballooned neurons. A transitional form of the disease between common iatrogenic and panencephalopathic CJD is suggested.

References

Jun 15, 1991·Lancet·J CollingeA J Dryden
May 1, 1990·Journal of Neuropathology and Experimental Neurology·Y NakazatoT Fukuda
Jul 7, 1990·Lancet·J CollingeP L Lantos
Dec 1, 1987·Journal of the Neurological Sciences·F Cruz-SanchezG Stoltenburg-Didinger
Feb 1, 1984·Journal of the Neurological Sciences·G MacchiA Sbriccoli
Feb 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·T MizutaniH Shiraki
Sep 1, 1996·Neurology·T Billette de VillemeurY Agid
Nov 9, 2000·Neurology·P BrownS J Collins
Aug 15, 2003·The Journal of Biological Chemistry·Wen-Quan ZouShu G Chen
Mar 24, 2004·Neurology·A PalminiH V Vinters
Jul 23, 2005·Annals of Neurology·Constanze BoesenbergInga Zerr
Sep 22, 2006·The Journal of Biological Chemistry·Jue YuanWen-Quan Zou
Jan 10, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yasushi IwasakiGen Sobue
Mar 3, 2010·The Journal of Biological Chemistry·Wen-Quan ZouJian-Ping Guo

❮ Previous
Next ❯

Citations

Oct 10, 2013·Scientific Reports·Jue YuanWen-Quan Zou
Mar 12, 2019·Journal of Neuropathology and Experimental Neurology·Colleen E D'ArcyGerard H Jansen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.