CRF-like diuretic hormone negatively affects both feeding and reproduction in the desert locust, Schistocerca gregaria.

PloS One
Pieter Van WielendaeleJozef Vanden Broeck

Abstract

Diuretic hormones (DH) related to the vertebrate Corticotropin Releasing Factor (CRF) have been identified in diverse insect species. In the migratory locust, Locusta migratoria, the CRF-like DH (CRF/DH) is localized in the same neurosecretory cells as the Ovary Maturating Parsin (OMP), a neurohormone that stimulates oocyte growth, vitellogenesis and hemolymph ecdysteroid levels in adult female locusts. In this study, we investigated whether CRF-like DH can influence feeding and reproduction in the desert locust, Schistocerca gregaria. We identified two highly similar S. gregaria CRF-like DH precursor cDNAs, each of which also encodes an OMP isoform. Alignment with other insect CRF-like DH precursors shows relatively high conservation of the CRF/DH sequence while the precursor region corresponding to OMP is not well conserved. Quantitative real-time RT-PCR revealed that the precursor transcripts mainly occur in the central nervous system and their highest expression level was observed in the brain. Injection of locust CRF/DH caused a significantly reduced food intake, while RNAi knockdown stimulated food intake. Therefore, our data indicate that CRF-like DH induces satiety. Furthermore, injection of CRF/DH in adult females reta...Continue Reading

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Citations

Mar 26, 2013·Journal of Insect Physiology·Pieter Van WielendaeleJozef Vanden Broeck
Oct 30, 2012·Insect Biochemistry and Molecular Biology·Pieter Van WielendaeleJozef Vanden Broeck
Aug 1, 2015·Insect Biochemistry and Molecular Biology·Neil Audsley, Rachel E Down
Oct 16, 2015·Journal of the American Society for Mass Spectrometry·Jelle CaersMatthias B Van Hiel
Aug 27, 2014·General and Comparative Endocrinology·Hans Peter VandersmissenJozef Vanden Broeck
Oct 2, 2012·Insect Biochemistry and Molecular Biology·Niels WynantJozef Vanden Broeck
Jan 17, 2017·Insect Biochemistry and Molecular Biology·Juan Pedro WulffSheila Ons
Jul 12, 2017·General and Comparative Endocrinology·Shirin MollayevaAngela B Lange
Jan 29, 2019·Frontiers in Physiology·Elise VogelJozef Vanden Broeck

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Datasets Mentioned

BETA
JN591547
JN591548

Methods Mentioned

BETA
Rapid Amplification
dissection
PCR
electrophoresis
Assay
amidation

Software Mentioned

Primer Express
Statistica
GraphPad Prism
StepOne
geNorm Excel
ClustalW
Statsoft
Locmi
geNorm

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