PMID: 9535058Apr 16, 1998Paper

CRFergic innervation of the paraventricular nucleus of the rat hypothalamus: a tract-tracing study

Journal of Neuroendocrinology
D ChampagneG Drolet

Abstract

It has been reported that corticotropin-releasing factor (CRF) may regulate its own biosynthesis in the paraventricular nucleus of the hypothalamus (PVH). Whether this CRF autoregulation is mediated by local circuitry or from extra-PVH CRF neuronal fibers terminating on CRF perikarya within the PVH is unknown. In the present study, we sought to determine the origin(s) of this CRF innervation using retrograde transport of wheat germ-conjugated-gold particles (WGA-apoHRP-Au) combined with immunohistochemistry for CRF. The rats also received colchicine (100 microg, icv) 5-7 days after tracer injection and were perfused 24 h later. Results of retrograde labeling with pressure injections of WGA-apoHRP-Au centered to PVH and subsequent immunohistochemical staining for CRF demonstrated numerous retrogradely labeled CRF neurons in the perifornical hypothalamic nucleus (PeF), the dorsolateral hypothalamic area (DA) (medial and lateral portions) and the dorsomedial nucleus of the hypothalamus (DMH). Smaller groups of CRF-ir neurons that were retrogradely labeled were found in the bed nuclei of the stria terminalis (BnST), the Barrington's nucleus (Bar) and the dorsal raphé (DR). These CRFergic pathways to the PVH may represent an anatomi...Continue Reading

References

Oct 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C Adams
Apr 8, 1990·The Journal of Comparative Neurology·I J Llewellyn-SmithA J Hodgson
Jul 1, 1989·Journal of Neuroscience Methods·G JuL Z Fan
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N OnoS M McCann
Feb 1, 1986·Brain Research Bulletin·G J ter Horst, P G Luiten
Jan 1, 1981·Brain Research Bulletin·A J SilvermanE A Zimmerman
Aug 1, 1994·The Journal of Comparative Neurology·M M Moga, C B Saper
Jan 1, 1993·Ciba Foundation Symposium·G F KoobK T Britton
Jan 1, 1993·Ciba Foundation Symposium·P E SawchenkoW Vale
Apr 22, 1996·The Journal of Comparative Neurology·W E CullinanS J Watson

❮ Previous
Next ❯

Citations

Apr 3, 2001·Annual Review of Neuroscience·A G Watts
Jun 16, 2007·The Journal of Comparative Neurology·Martin Williamson, Victor Viau
Apr 27, 2004·Neuroreport·Morten P KristensenRonald M Harper
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·C Rivier
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn G CommonsRita J Valentino
Sep 8, 2010·Nature Neuroscience·J Brent KuzmiskiJaideep S Bains
Aug 31, 2004·The Journal of Comparative Neurology·Christopher V DayasTrevor A Day
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman
May 24, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kelly L ConradDanny G Winder
May 11, 2018·Stress : the International Journal on the Biology of Stress·Marianela Masis-CalvoInga D Neumann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.