Cribriform architecture in radical prostatectomies predicts oncological outcome in Gleason score 8 prostate cancer patients.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Eva HollemansGeert J L H van Leenders

Abstract

The Gleason score is an important parameter for clinical outcome in prostate cancer patients. Gleason score 8 is a heterogeneous disease including Gleason score 3 + 5, 4 + 4, and 5 + 3 tumors, and encompasses a broad range of tumor growth patterns. Our objective was to characterize individual growth patterns and identify prognostic parameters in Gleason score 8 prostate cancer patients. We reviewed 1064 radical prostatectomy specimens, recorded individual Gleason 4 and 5 growth patterns as well as presence of intraductal carcinoma, and evaluated biochemical recurrence- and metastasis-free survival. Gleason score 8 disease was identified in 140 (13%) patients, of whom 76 (54%) had Gleason score 3 + 5, 46 (33%) 4 + 4, and 18 (13%) 5 + 3 disease. Invasive cribriform and/or intraductal carcinoma (n = 87, 62%) was observed more frequently in Gleason score 4 + 4 (93%) than 3 + 5 (47%; P < 0.001) and 5 + 3 (44%; P < 0.001) patients. Gleason pattern 5 was present in 110 (79%) men: as single cells and/or cords in 99 (90%) and solid fields in 32 (29%) cases. Solid field pattern 5 coexisted with cribriform architecture (23/32, 72%) more frequently than nonsolid pattern 5 cases (36/78, 46%, P = 0.02). In multivariable analysis including ag...Continue Reading

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Mar 16, 2019·Pathology Oncology Research : POR·Thomas Chengxuan LuMichael O'Callaghan

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Citations

Feb 19, 2021·The Journal of Pathology. Clinical Research·Amanda B HesterbergPaula J Hurley
Jun 1, 2021·Urology·Amanda B HesterbergPaula J Hurley
Jun 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tim HansumGeert J L H van Leenders
Jun 2, 2021·The Journal of Molecular Diagnostics : JMD·Daniela C SallesTamara L Lotan

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BETA
biopsy
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SPSS

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