Cr(III) reactivity and foot dermatitis in Cr(VI) positive patients

Contact Dermatitis
Malene Barré HansenJ D Johansen

Abstract

Chromium allergy has become synonymous with Cr(VI) allergy. However, real exposure to chromium from leather products may include both Cr(III) and Cr(VI). In this study, we investigate the reactivity to both Cr(VI) and Cr(III) in consecutive patients to analyse the relation between foot eczema/leather exposure and reactivity to Cr(III). From March 2002 to December 2004, 2211 consecutive patients with suspected allergic contact dermatitis were patch tested with 0.5% potassium dichromate (Cr(VI)) and 13% chromium trichloride (Cr(III)). A total of 71 (3.2%) patients had a positive reaction to Cr(VI), of which 31 also had a positive Cr(III) reaction. No Cr(VI) negative patients had a positive reaction to Cr(III). An increased risk of foot dermatitis was found in Cr(VI) positive patients with a concomitant positive or doubtful reaction to Cr(III) compared with Cr(VI) positive patients with no reactions to Cr(III). The increased risk was not due to a higher degree of sensitivity to Cr(VI). Leather was reported most frequently as the suspected cause of chromium dermatitis (54%). However, Cr(VI) allergics having foot eczema and positive or doubtful Cr(III) reactions often had positive reactions to other shoe allergens. Thus, Cr(III) all...Continue Reading

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Citations

Aug 14, 2010·Archives of Environmental & Occupational Health·Madiha SyedKamran Sadiq
Nov 21, 2007·Dermatitis : Contact, Atopic, Occupational, Drug·Erin M WarshawKathryn A Zug
Jul 8, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Erin MatthysAlison Ehrlich
Aug 14, 2009·The British Journal of Dermatology·J P ThyssenJ D Johansen
Apr 11, 2012·Contact Dermatitis·Jacob P ThyssenJeanne D Johansen
Dec 23, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Diane AntoniosMarc Pallardy
Jun 15, 2007·Journal of Pharmaceutical and Biomedical Analysis·B BoccaA Cristaudo
Mar 25, 2018·Contact Dermatitis·Tina LejdingMalin Engfeldt
Oct 13, 2017·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kenneth T Bogen, Michael R Garry
Oct 28, 2019·Contact Dermatitis·Tina LejdingMartin Mowitz
Nov 30, 2018·Contact Dermatitis·Yolanda S HedbergFederico Moncada Chévez
May 28, 2019·Contact Dermatitis·Angela TewariLucy Ostlere

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