Cripto-1 enhances migration and branching morphogenesis of mouse mammary epithelial cells

Experimental Cell Research
C WechselbergerD S Salomon

Abstract

Cripto-1 is an EGF-CFC protein that performs an important role during early vertebrate development and is overexpressed in several types of human cancer. In the present study mouse EpH4, NMuMG, and TAC-2 mammary epithelial cells that are negative for endogenous cripto-1 expression were transfected with the murine cripto-1 cDNA. Cripto-1-transfected cell lines exhibited functional and physiological differences from the original cell lines including enhanced anchorage-independent growth in soft agar (EpH4 cells), growth in serum-free medium, increased proliferation, and formation of branching, duct-like structures when grown in a three-dimensional collagen type I matrix. Furthermore, cripto-1-expressing cell lines showed elevated migration in vitro in Boyden chamber and wound-healing assays. These results indicate that cripto-1 can function through an autocrine pathway that enables mammary epithelial cells to undergo an epithelial to mesenchymal transition.

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Citations

May 22, 2010·Journal of Mammary Gland Biology and Neoplasia·Douglas S MicalizziHeide L Ford
Jan 20, 2005·Journal of the National Cancer Institute·Caterina BiancoDavid S Salomon
Oct 13, 2006·Molecular and Cellular Biology·Peter C GrayWylie Vale
Mar 23, 2002·Molecular and Cellular Biology·Caterina BiancoDavid S Salomon
Sep 15, 2011·PloS One·Michael MurrellPaul Matsudaira
Jul 14, 2010·Future Oncology·Nadia Pereira de CastroCaterina Bianco
Aug 27, 2005·Oncogene·Luigi StrizziDavid Salomon
Nov 16, 2010·Expert Opinion on Therapeutic Patents·Caterina Bianco, David S Salomon
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Jan 19, 2008·The American Journal of Pathology·Caterina BiancoDavid S Salomon
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Nov 26, 2015·The Clinical Respiratory Journal·Chun Hua XuQing Bo Wang
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Sep 13, 2018·Current Medicinal Chemistry·Annamaria Sandomenico, Menotti Ruvo
Nov 8, 2017·Oncotarget·Hua ZhangChangli Wang

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