PMID: 3754547Mar 1, 1986Paper

Crisamicin A, a new antibiotic from Micromonospora. I. Taxonomy of the producing strain, fermentation, isolation, physico-chemical characterization and antimicrobial properties

The Journal of Antibiotics
R A NelsonC P Schaffner

Abstract

A microorganism, designated as RV-79-9-101 and now identified as Micromonospora purpureochromogenes subsp. halotolerans, isolated from a mud sample in the Philippines, has been shown to produce a complex of antibiotics called crisamicins. Thin-layer chromatography and bioautography, employing solvent extracts of whole fermentation broths, revealed a minimum of five antimicrobial components. The major biologically-active component of the antibiotic complex, crisamicin A, was obtained in pure form after preparative silica gel column chromatography followed by crystallization. Based on physico-chemical data crisamicin A has been identified as a novel member of the isochromanequinone group of antibiotics. It exhibits excellent in vitro activity against Gram-positive bacteria but little or no activity towards Gram-negative bacteria or fungi.

Citations

Jun 17, 2008·Organic Letters·Zhengtao LiZhen Yang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhanna Mohammed Al-ShaibaniNoraziah Mohamad Zin
Sep 21, 2010·The Journal of Organic Chemistry·Rodney A Fernandes, Sandip V Mulay
Jul 17, 2014·The Journal of Organic Chemistry·Margaret A BrimbleJonathan Sperry

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