CRISPR-Cas Adaptive Immune Systems of the Sulfolobales: Unravelling Their Complexity and Diversity

Life
Roger A GarrettQunxin She

Abstract

The Sulfolobales have provided good model organisms for studying CRISPR-Cas systems of the crenarchaeal kingdom of the archaea. These organisms are infected by a wide range of exceptional archaea-specific viruses and conjugative plasmids, and their CRISPR-Cas systems generally exhibit extensive structural and functional diversity. They carry large and multiple CRISPR loci and often multiple copies of diverse Type I and Type III interference modules as well as more homogeneous adaptation modules. These acidothermophilic organisms have recently provided seminal insights into both the adaptation process, the diverse modes of interference, and their modes of regulation. The functions of the adaptation and interference modules tend to be loosely coupled and the stringency of the crRNA-DNA sequence matching during DNA interference is relatively low, in contrast to some more streamlined CRISPR-Cas systems of bacteria. Despite this, there is evidence for a complex and differential regulation of expression of the diverse functional modules in response to viral infection. Recent work also supports critical roles for non-core Cas proteins, especially during Type III-directed interference, and this is consistent with these proteins tending...Continue Reading

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Citations

Oct 16, 2015·Nucleic Acids Research·Yingjun LiQunxin She
Sep 3, 2016·Bioinformatics·Omer S AlkhnbashiRolf Backofen
Mar 16, 2018·Physical Biology·Melia E Bonomo, Michael W Deem
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Apr 3, 2019·Journal of Bacteriology·Zhufeng ZhangNan Peng
May 29, 2018·Drug Delivery·Christopher A LinoJerilyn A Timlin
May 16, 2017·Nature Reviews. Microbiology·Alexander WagnerSonja-Verena Albers
Nov 4, 2020·Science China. Life Sciences·Zhenxiao YuQunxin She
Feb 6, 2016·Genes & Development·Michael A EstrellaScott Bailey

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Methods Mentioned

BETA
NMR

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