CRISPR-Cas Systems Reduced to a Minimum

Molecular Cell
Cristóbal AlmendrosStan J J Brouns

Abstract

In two recent studies in Molecular Cell, Wright et al. (2019) report complete spacer integration by a Cas1 mini-integrase and Edraki et al. (2019) describe accurate genome editing by a small Cas9 ortholog with less stringent PAM requirements.

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