CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders

Indian Journal of Pediatrics
Sivaprakash Ramalingam, Saravanabhavan Thangavel

Abstract

The ability to precisely change the deoxyribonucleic acid (DNA) bases at specific sites offers tremendous advantages in the field of molecular biology and medical biotechnology. Identification of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), revelation of its role in prokaryotic adaptive immunity and subsequent conversion into genome and epigenome engineering system are the landmark research progresses of the decade. The possibilities of deciphering the molecular mechanisms of the disease, identifying the disease targets, generating the disease models, validating the drug targets, developing resistance to the infection and correcting the genotype have brought off much enthusiasm in the field of infectious diseases and genetic disorders. This review focuses on CRISPR/Cas9's impact in the field of infection and genetic disorders.

References

Oct 28, 2005·Nucleic Acids Research·Sundar DuraiSrinivasan Chandrasegaran
Dec 23, 2008·Nature·Allison D EbertClive N Svendsen
Jan 5, 2013·Science·Le CongFeng Zhang
Jan 5, 2013·Science·Prashant MaliGeorge M Church
Dec 18, 2013·Science·Tim WangEric S Lander
Mar 7, 2014·The New England Journal of Medicine·Pablo TebasCarl H June
Sep 24, 2014·Current Gene Therapy·Sivaprakash RamalingamSrinivasan Chandrasegaran
Sep 9, 2016·Nature Biotechnology·Rodolphe Barrangou, Jennifer A Doudna
Oct 14, 2016·Science Translational Medicine·Mark A DeWittJacob E Corn
Apr 5, 2017·Annual Review of Biophysics·Fuguo Jiang, Jennifer A Doudna
Apr 15, 2017·Science·Jonathan S GootenbergFeng Zhang
Jan 6, 2018·ELife·Steven C StruttJennifer A Doudna
Sep 19, 2018·Journal of Cytokine Biology·Mollie S SchubertMarina A Dobrovolskaia
Nov 16, 2018·Journal of Clinical Microbiology·Jeffrey R Strich, Daniel S Chertow
Feb 6, 2019·Nature·Jun-Jie LiuJennifer A Doudna
Apr 28, 2019·Nature Communications·Mara Pavel-DinuMatthew H Porteus

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.