CRISPR-Cas9 therapies in experimental mouse models of cancer

Future Oncology
Diogo EstêvãoRui Medeiros

Abstract

The CRISPR-Cas9, a part of the defence mechanism from bacteria, has rapidly become the simplest, fastest and the most precise genome-editing tool available. The therapeutic applications of CRISPR are boundless: correction of mutations in several disorders, inactivation of oncogenes and viral oncoproteins, and activation of tumor suppressor genes. In this review, we expose recent advances concerning animal models of cancer that use CRISPR-Cas9, addressing also the current efforts to develop CRISPR-Cas9-based therapies, focusing on proof-of-concept studies. Finally, the review exposes some of the main challenges that this genome-editing tool faces. The key issue remains: does CRISPR-Cas9 have real potential for therapeutic application or will it just remain a wonderful research tool?

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·E S RobertsonE D Kieff
Oct 19, 2001·Oncogene·L M Boxer, C V Dang
Jun 17, 2004·The Journal of Clinical Investigation·Yasuo HorieToru Nakano
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
Jul 4, 2007·Nature Reviews. Genetics·Reinhard WaehlerDavid T Curiel
Jan 19, 2008·Biochimica Et Biophysica Acta·Margaret E McLaughlin-Drubin, Karl Munger
Mar 21, 2008·Expert Opinion on Biological Therapy·Chien-Fu HungT-C Wu
Apr 2, 2008·The American Journal of Surgical Pathology·Leonard Da SilvaPeter T Simpson
Oct 16, 2008·Clinical Microbiology Reviews·Shyam Daya, Kenneth I Berns
Oct 25, 2008·Nature·Li DingRichard K Wilson
Dec 20, 2008·Science·Luciano A Marraffini, Erik J Sontheimer
Jan 15, 2009·The Journal of Pathology·Irene BottilloBruno Dallapiccola
Apr 8, 2009·The Lancet Oncology·Véronique BouvardUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Nov 17, 2009·Advances in Genetics·Stefan Michelfelder, Martin Trepel
Dec 17, 2009·Journal of Neuropathology and Experimental Neurology·Robert M VerdijkJohan M Kros
May 25, 2010·Progress in Biophysics and Molecular Biology·Liling TangClaudio Ciferri
Jun 10, 2010·Annual Review of Microbiology·Hélène DeveauSylvain Moineau
Aug 19, 2010·Nature Reviews. Genetics·Fyodor D UrnovPhilip D Gregory
Nov 5, 2010·Nature·Josiane E GarneauSylvain Moineau
Feb 15, 2011·Future Virology·Vonetta M WilliamsPenelope J Duerksen-Hughes
Apr 2, 2011·Nature·Elitza DeltchevaEmmanuelle Charpentier
Jun 18, 2011·The Prostate·Min Pi, L Darryl Quarles
Jul 23, 2011·Genes & Cancer·Rónán C O'Hagan, Joerg Heyer
Aug 5, 2011·Nucleic Acids Research·Rimantas SapranauskasVirginijus Siksnys
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela Cilloni, Giuseppe Saglio
Mar 23, 2012·Journal of Hematology & Oncology·Véronique Gelsi-BoyerDaniel Birnbaum
May 5, 2012·North American Journal of Medical Sciences·Rajeev SinghaiAmit V Patil
Jun 30, 2012·Science·Martin JinekEmmanuelle Charpentier
Jan 5, 2013·Science·Le CongFeng Zhang
Feb 14, 2013·RNA Biology·Shiraz A ShahRoger A Garrett
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Oct 26, 2013·Nature Protocols·F Ann RanFeng Zhang

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Methods Mentioned

BETA
xenografting
transgenic

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