CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point-of-Care Diagnosis.

Angewandte Chemie
Yifan DaiJ Justin Gooding

Abstract

Recent advances in CRISPR based biotechnologies have greatly expanded our capabilities to repurpose CRISPR for the development of biomolecular sensors for diagnosing diseases and understanding cellular pathways. The key attribute that allows CRISPR to be widely utilized is the programmable and highly selective mechanism. In this Minireview, we first illustrate the molecular principle of CRISPR functioning process from sensing to actuating. Next, the CRISPR based biosensing strategies for nucleic acids, proteins and small molecules are summarized. We highlight some of recent advances in applications for in vitro detection of biomolecules and in vivo imaging of cellular networks. Finally, the challenges with, and exciting prospects of, CRISPR based biosensing developments are discussed.

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Citations

Jan 8, 2021·Biosensors & Bioelectronics·Peng-Fei LiuGuo-Xi Liang
Mar 3, 2021·Analytical Chemistry·Anzhi ShengJuan Zhang
May 11, 2021·Frontiers in Cellular and Infection Microbiology·Ronghua DingGuangcai Duan
Aug 22, 2021·Biosensors & Bioelectronics·Lijuan YinLong Ma
Oct 7, 2021·Chemical Society Reviews·Yanan TangX Chris Le
Oct 26, 2021·Journal of Agricultural and Food Chemistry·Ting ZhangRuijie Deng
Dec 3, 2021·Nano-micro Letters·Cheng JiangGeorge K Tofaris
Jan 23, 2022·Journal of Nanobiotechnology·Julija DroninaArunas Ramanavicius

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