CRISPR Shields: Fending Off Diverse Cas Nucleases with Nucleus-like Structures

Molecular Cell
Rodolphe Barrangou, Erik J Sontheimer

Abstract

Two recent studies have uncovered a novel means by which bacteriophages thwart host immunity. Mendoza et al. (2020) and Malone et al. (2020) demonstrate that a nucleus-like proteinaceous structure shields phage DNA from CRISPR-associated nucleases encompassing Cascade-Cas3, Cas9, and Cas12.

References

Dec 18, 2012·Nature·Joe Bondy-DenomyAlan R Davidson
Jan 14, 2017·Science·Vorrapon ChaikeeratisakJoe Pogliano
Jan 30, 2019·Nature Microbiology·Jakob T Rostøl, Luciano A Marraffini
May 31, 2019·Nature·Alexander J MeeskeLuciano A Marraffini
Dec 11, 2019·Nature·Senén D MendozaJoseph Bondy-Denomy
Dec 21, 2019·Nature Reviews. Microbiology·Kira S MakarovaEugene V Koonin
Jan 17, 2020·Nature·Hannah G HamptonPeter C Fineran

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