CRISPR/Cas13a targeting of RNA virus in plants.

Plant Cell Reports
Kul Bhushan

Abstract

This approach is quite promising to control plant viral diseases and create synthetic networks to better understand the structure/function relationship in RNA and proteins. Plant viruses are obligate intracellular parasites which causes enormous losses in crop yield worldwide. These viruses replicate into infected cells by highjacking host cellular machinery. Over the last two decades, diverse approaches such as conventional breeding, transgenic approach and gene silencing strategies have been used to control RNA viruses, but escaped due to high rate of mutation. Recently, a novel CRISPR enzyme, called Cas13a, has been used engineered to confer RNA viruses resistance in plants. Here, we summarize the recent breakthrough of CRISPR/Cas13a and its applications in RNA biology.

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Citations

Feb 26, 2019·Plant Biotechnology Journal·Xiaohui ZhanJiang Zhang
Mar 30, 2019·Plant Cell Reports·Günther HahneFabien Nogué
Jul 28, 2019·The Plant Journal : for Cell and Molecular Biology·Alberto CarbonellJosé-Antonio Daròs
Feb 16, 2021·Frontiers in Microbiology·Muhammad Shafiq ShahidAbdullah M Al-Sadi

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Methods Mentioned

BETA
transgenic

Software Mentioned

SHERLOCK ( Enzymatic Reporter unLOCKing

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