Apr 9, 2020

Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin

BioRxiv : the Preprint Server for Biology
J. A. HaywardGilda Tachedjian

Abstract

Bats are recognized as important reservoirs of viruses deadly to other mammals, including humans. These infections are typically nonpathogenic in bats raising questions about innate immune differences that might exist between bats and other mammals. Tetherin is an important restriction factor which inhibits the release of a diverse range of viruses from host cells, including retroviruses, coronaviruses, filoviruses, and paramyxoviruses, some of which are deadly to humans and transmitted by bats. Here we characterise the tetherin genes from 27 species of bats, revealing that they are under strong selective pressure, and that fruit bats and vesper bats express unique structural variants of the tetherin protein. The expression of two computationally predicted splice isoforms of fruit bat tetherin is verified here, and we identify an additional third unique splice isoform which includes a C-terminal region that is not homologous to known mammalian tetherin variants. We also report that vesper bats possess and express at least five tetherin genes, including structural variants, a greater number than any other mammal reported to date. These findings support the hypothesis of differential antiviral gene evolution in bats relative to o...Continue Reading

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Mentioned in this Paper

Computer Software
Non-Homologous DNA End-Joining
Biochemical Pathway
Genome
DNA Repair
RNA, Untranslated
Genome Assembly Sequence
Nucleic Acid Sequencing
Cytokinesis of the Fertilized Ovum
Gene Amplification Technique

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