Criteria for neuropathic abnormality in quantitative anal sphincter electromyography

Muscle & Nerve
S Podnar

Abstract

For the external anal sphincter muscle, both normative values and an optimal set of motor unit potential (MUP) parameters have been defined. However, criteria for the diagnosis of neuropathic conditions have not yet been validated. Therefore, in this study, sensitivity was examined in 86 patients with cauda equina lesions (227 muscles), and specificity in 77 controls (119 muscles), using multi-MUP analysis. Six previously defined diagnostic criteria (mean values and outliers for MUP area, duration, and number of turns) were used. An increase in the number of diagnostic criteria required for muscle abnormality (two and three instead of one), and the application of more stringent normative limits resulted in a progressive increase in specificity from 74% to 99% (controls), and a decrease in sensitivity from 70% to 21% (patients). The data suggest that no single cut-off diagnostic criterion has both satisfactory sensitivity and specificity. Introduction of the diagnostic categories of "possible," "probable," and "definite" neuropathic abnormalities into quantitative electromyographic analysis is proposed.

References

Jun 1, 1988·Electroencephalography and Clinical Neurophysiology·S D NandedkarE V Stålberg
Aug 1, 1988·Muscle & Nerve·L J Dorfman, K C McGill
Jun 1, 1995·Electroencephalography and Clinical Neurophysiology·E StålbergM Aström
Apr 1, 1994·Muscle & Nerve·E StålbergB Falck
Jan 1, 1997·Muscle & Nerve·L J Dorfman, L R Robinson
Mar 23, 1999·Muscle & Nerve·S PodnarD B Vodusek
Aug 24, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S Podnar, D B Vodusek
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·F TisonF Yeklef
Dec 18, 2001·Neurourology and Urodynamics·S Podnar, D B Vodusek
Dec 26, 2001·Muscle & Nerve·Simon PodnarErik Stålberg

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Citations

Sep 22, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Simon Podnar
Jan 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Podnar
May 12, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adil E BharuchaAlan R Zinsmeister
Dec 9, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G AmarencoF Haab
Mar 31, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simon Podnar
Sep 2, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L J PinoS Podnar
Aug 19, 2007·Medical Engineering & Physics·L J PinoT J Doherty
May 1, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simon Podnar
Mar 25, 2009·Neurourology and Urodynamics·Simon Podnar
Dec 19, 2008·Neurourology and Urodynamics·Simon Podnar
Dec 5, 2006·Muscle & Nerve·Simon Podnar
Jul 22, 2008·Neurourology and Urodynamics·Simon Podnar
Oct 27, 2010·Neurourology and Urodynamics·Simon Podnar, W Thomas Gregory
Jan 22, 2011·Neurourology and Urodynamics·Simon Podnar
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simon PodnarIrena Hausmanowa-Petrusewicz
Jul 9, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simon Podnar
Jul 22, 2014·Neurourology and Urodynamics·Fan JianXiaofu Tang
Oct 4, 2019·Muscle & Nerve·Mark B Bromberg

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