Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.

Human Pathology
Amy A SwansonJ Kenneth Schoolmeester

Abstract

Data have shown that uterine diagnostic criteria are universal for smooth muscle tumors (SMTs) originating in the ovary, vulva, vagina, broad ligament, and other supportive connective tissue and that uterine criteria outperform site-specific criteria for vulvar and vaginal SMTs. Classic benign and malignant spindled SMTs were well represented in our recent study comparing uterine and site-specific criteria in vulvovaginal SMTs, but leiomyoma variants and smooth muscle tumors of uncertain malignant potential (STUMPs) were relatively few. Therefore, we evaluated additional leiomyoma variants, STUMPs, and leiomyosarcomas from 17 patients (10 vaginal and 7 vulvar). The 10 vaginal tumors (59%) comprised cellular leiomyoma (n = 2), leiomyoma with bizarre nuclei (n = 3), STUMP (n = 1), and leiomyosarcoma (n = 4). The 7 vulvar tumors (41%) comprised leiomyoma with bizarre nuclei (n = 3), STUMP (n = 1), and leiomyosarcoma (n = 3). Follow-up was available for 13 patients (76.5%) ranging from 1 to 97 months (mean: 17.3; median: 7). Follow-up for some patients with leiomyosarcoma was limited (≤4 months for 4 patients). One vaginal STUMP locally recurred after 19 months, and 2 patients diagnosed with leiomyosarcoma developed distant metasta...Continue Reading

References

Jul 1, 1996·The American Journal of Surgical Pathology·G P NielsenR E Scully
Apr 5, 2013·The American Journal of Surgical Pathology·Diana LimEsther Oliva
Feb 1, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Vatsal PatelJohn Kenneth Schoolmeester
May 18, 2019·Surgical Pathology Clinics·Kelly A Devereaux, J Kenneth Schoolmeester

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Citations

Sep 23, 2020·Seminars in Diagnostic Pathology·David B ChapelJennifer A Bennett
Jun 9, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J Kenneth SchoolmeesterDavid L Kolin

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