PMID: 2097025Dec 1, 1990Paper

Criteria to indicate testosterone administration

British Journal of Sports Medicine
A T KicmanM J Wheeler

Abstract

A detection method for testosterone administration was developed using radioimmunoassay to measure the urinary ratios of testosterone (T) to epitestosterone (E) and to luteinizing hormone (LH). A comparative study of the effect on these ratios of a single intramuscular injection of testosterone heptanoate followed by stimulation with human chorionic gonadotrophin (HCG) in three normal men was undertaken. To allow immediate investigation, a commercially supplied epitestosterone antiserum was used. This study showed that both T/E and T/LH ratios could be used to detect testosterone administration, the latter also being an indicator of HCG use due to cross-reactivity with the LH antiserum. Subsequently, an epitestosterone antiserum of superior specificity was raised and used in a study to demonstrate the insignificant effect of exercise on these ratios. Finally, an intramuscular injection of a combined preparation of testosterone/epitestosterone heptanoates resulted in raised ratios of T/LH but not of T/E. This demonstrated the importance of the T/LH ratio in circumstances where the T/E ratio can be easily circumvented.

References

Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·T M JonesR Rosenfield
Jul 1, 1979·Journal of Steroid Biochemistry·R V BrooksM Wheeler
Dec 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P C MacDonaldP K Siiteri
Jul 1, 1975·British Journal of Sports Medicine·R V BrooksN A Sumner
Aug 14, 1986·The New England Journal of Medicine·S E MacConnieI Z Beitins
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·B S KeenanW B Panko
Aug 1, 1966·The Journal of Clinical Endocrinology and Metabolism·H Wilson, M B Lipsett
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S R PlymateA E Karpas
Oct 1, 1980·Journal of Endocrinological Investigation·E RuizC Osorio
May 1, 1983·Journal of Reproduction and Fertility·D Mortimer, E A Lenton
May 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R F Casper, S S Yen
Sep 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·K KuoppasalmiH Adlercreutz

❮ Previous
Next ❯

Citations

Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·M MaynarJ I Maynar
Apr 11, 1992·Lancet·H Oftebro
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·G J SouthanC J Walker
Jul 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·H R NorliP Hemmersbach
Oct 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·E PalonekK Carlström
Mar 15, 2005·Steroids·Christophe SaudanMartial Saugy
Dec 1, 2001·Steroids·Shi Hua PengXavier de la Torre
Apr 4, 2008·Asian Journal of Andrology·Kenneth D Fitch
Apr 4, 2008·Asian Journal of Andrology·David J Handelsman, Alison Heather
Aug 5, 2004·Science's STKE : Signal Transduction Knowledge Environment·David J Handelsman
Jun 27, 2006·British Journal of Sports Medicine·C SaudanM Saugy
Jun 1, 1991·British Journal of Sports Medicine·A T KicmanD A Cowan
Sep 28, 2002·British Journal of Sports Medicine·R M N Kohler, M I Lambert
Jul 22, 2009·Journal of Strength and Conditioning Research·Jay R HoffmanAlan D Rogol
Dec 1, 2010·Journal of Strength and Conditioning Research·Andrew C FryWilliam J Kraemer
May 21, 2008·Sports Medicine·Michael R GrahamJulien S Baker
Feb 6, 2014·The Journal of Steroid Biochemistry and Molecular Biology·David J HandelsmanAnn J Conway
Jan 25, 2012·Forensic Science International : Synergy·Yvonne LoodJohan Ahlner
Oct 11, 2011·Hormones and Behavior·Ruth I Wood, Steven J Stanton
Jan 28, 2009·Clinical Endocrinology·David J HandelsmanRymantas Kazlauskas
Apr 17, 2008·British Journal of Pharmacology·U-H StenmanH Alfthan
Apr 23, 2013·Drug Testing and Analysis·Gurmeet Kaur Surindar SinghDavid J Handelsman
Apr 26, 2014·British Journal of Sports Medicine·Tiia KuuranneNorbert Baume
May 2, 2014·Frontiers in Endocrinology·Jenny J SchulzeAngelica Lindén Hirschberg
Apr 1, 1993·Clinical Endocrinology·M J Wheeler
Nov 18, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P Van RenterghemF T Delbeke
Jan 25, 2006·Scandinavian Journal of Medicine & Science in Sports·N BaumeM Saugy
Feb 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Shehzad Basaria
Aug 1, 1996·Therapeutic Drug Monitoring·J Segura
Nov 11, 2014·Expert Review of Proteomics·Mario ThevisWilhelm Schänzer
Dec 6, 1996·Journal of Chromatography. B, Biomedical Applications·T KarilaT Seppälä
Jul 10, 1999·Journal of Chromatography. a·B G Wolthers, G P Kraan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.