Critical analysis of the performance of double-contrast barium enema for detecting colorectal polyps > or = 6 mm in the era of CT colonography

AJR. American Journal of Roentgenology
Jacob SosnaEugene Libson

Abstract

The purpose of our study was to perform a meta-analysis comparing the performance of double-contrast barium enema (DCBE) with CT colonography (CTC) for the detection of colorectal polyps > or = 6 mm using endoscopy as the gold standard. Prospective DCBE and CTC studies were identified. Percentages of polyps and of patients with polyps > or = 10 mm and 6-9 mm were abstracted. The performance of DCBE versus CTC was determined by separately evaluating each technique's performance versus that of endoscopy, and contrasting the techniques. The I-squared statistic and Fisher's exact test were used for heterogeneity, the Cochran-Mantel-Haenszel and the Kruskal-Wallis tests for correlation, and the A(z) test for comparing pooled weighted estimates of performance. Eleven studies of DCBE (5,995 patients, 1,548 polyps) and 30 studies of CTC (6,573 patients, 2,348 polyps) fulfilled inclusion criteria. For polyps > or = 10 mm, a 0.121-per-patient sensitivity difference favored CTC (p < 0.0001; DCBE, 0.702 [95% CI, 0.687-0.715]; CTC, 0.823 [0.809-0.836]). For polyps > or = 10 mm, a 0.031-per-polyp sensitivity difference favored CTC (p < 0.0001; DCBE, 0.715 [0.703-0.726]; CTC, 0.746 [0.735-0.757]). For polyps > or = 10 mm, a specificity differ...Continue Reading

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Citations

Apr 3, 2013·Nature Reviews. Clinical Oncology·Jaap Stoker
Aug 24, 2010·World Journal of Gastroenterology : WJG·Andrea LaghiCesare Hassan
Dec 24, 2010·Radiology·Marjolein H LiedenbaumJaap Stoker
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Dec 1, 2017·Khirurgiia·N N KrylovA B Komissarov
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Jan 30, 2019·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Gurjeet DulkuRichard Mendelson
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