Critical analysis of the potential for microRNA biomarkers in breast cancer management

Breast Cancer : Targets and Therapy
Carrie R GraveelLorenzo F Sempere

Abstract

Breast cancer is a complex and heterogeneous disease. Signaling by estrogen receptor (ER), progesterone receptor (PR), and/or human EGF-like receptor 2 (HER2) is a main driver in the development and progression of a large majority of breast tumors. Molecular characterization of primary tumors has identified major subtypes that correlate with ER/PR/HER2 status, and also subgroup divisions that indicate other molecular and cellular features of the tumors. While some of these research findings have been incorporated into clinical practice, several challenges remain to improve breast cancer management and patient survival, for which the integration of novel biomarkers into current practice should be beneficial. microRNAs (miRNAs) are a class of short non-coding regulatory RNAs with an etiological contribution to breast carcinogenesis. miRNA-based diagnostic and therapeutic applications are rapidly emerging as novel potential approaches to manage and treat breast cancer. Rapid technological development enables specific and sensitive detection of individual miRNAs or the entire miRNome in tissues, blood, and other biological specimens from breast cancer patients. This review focuses on recent miRNA research and its potential to addre...Continue Reading

Citations

Jun 13, 2015·International Journal of Molecular Sciences·Martyna O UrbanekWlodzimierz J Krzyzosiak
Oct 21, 2015·Critical Reviews in Oncology/hematology·Shivangi MishraVibha Rani
Dec 23, 2015·International Journal of Molecular Sciences·Tarek Shalaby, Michael A Grotzer
Apr 14, 2018·BioMed Research International·Jianing YanXiujun Cai
Oct 16, 2018·Frontiers in Endocrinology·Sergio LiarteFrancisco José Nicolás
Sep 19, 2020·International Journal of Molecular Sciences·Ishita GuptaHalema Al Farsi
Oct 8, 2020·International Journal of Molecular Sciences·Veronika HolubekovaZuzana Dankova

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Methods Mentioned

BETA
RNA-Seq
PCR
biopsies
biopsy

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