Critical Appraisal of the 2018 ACC Scientific Sessions Late-Breaking Trials From a Statistician's Perspective

Journal of the American College of Cardiology
Stuart J Pocock, Tim J Collier

Abstract

The late-breaking clinical trials presentations at the American College of Cardiology Scientific Sessions in March 2018 are an important contribution to the field of cardiology. This paper presents a constructive critical appraisal of 7 key studies: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), VEST (Vest Prevention of Early Sudden Death Trial), SECURE-PCI (Statins Evaluation in Coronary Procedures and Revascularization), TREAT (Ticagrelor in Patients with ST-Elevation Myocardial Infarction treated with Pharmacological Thrombolysis), POISE (PeriOperative ISchemic Evaluation), SMART-DATE (Safety of 6-Month Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome), and CVD-REAL 2 (Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors). For each study, our aim is to document and interpret the main findings, noting particularly when "positive spin" appears to occur, and to provide a balanced account of each study, paying attention to both constructive new findings and study limitations. These topical examples also provide useful general insights on what to look...Continue Reading

Citations

May 17, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·George Ntaios, Haralampos Milionis
Jun 16, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jens Cosedis Nielsen, Jens Brock Johansen
Jan 15, 2019·Circulation·Dharam J Kumbhani, Joseph A Hill
Mar 22, 2019·Frontiers in Cardiovascular Medicine·Nathan D Wong, Michael D Shapiro
Dec 21, 2018·Journal of the American Heart Association·John A Bittl
Feb 6, 2020·Herz·Gülmisal GüderChristiane E Angermann
Feb 1, 2020·Journal of the American College of Cardiology·Shaun G GoodmanUNKNOWN ODYSSEY OUTCOMES Investigators†

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Related Papers

JAMA : the Journal of the American Medical Association
Charanjit S RihalMalcolm R Bell
JAMA : the Journal of the American Medical Association
Jacek LegutkoLukasz Rzeszutko
JAMA : the Journal of the American Medical Association
Andrew T YanShaun G Goodman
© 2022 Meta ULC. All rights reserved