PMID: 22587289May 17, 2012Paper

Critical behavior and axis defining symmetry breaking in Hydra embryonic development

Physical Review Letters
Andrea GambaAlbrecht Ott

Abstract

The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.

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Citations

May 9, 2015·Biophysical Journal·Moritz MerckerAnna Marciniak-Czochra
Sep 13, 2019·The EMBO Journal·Nicoletta I Petridou, Carl-Philipp Heisenberg
Aug 25, 2019·Biophysical Journal·Rui WangEva-Maria S Collins
Nov 29, 2017·Developmental Biology·Kevin Chiou, Eva-Maria S Collins

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