Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

Virus Research
Ralf BartenschlagerTakaji Wakita

Abstract

The development and clinical implementation of direct-acting antivirals (DAAs) has revolutionized the treatment of chronic hepatitis C. Infection with any hepatitis C virus (HCV) genotype can now be eliminated in more than 95% of patients with short courses of all-oral, well-tolerated drugs, even in those with advanced liver disease and liver transplant recipients. DAAs have proven so successful that some now consider HCV amenable to eradication, and continued research on the virus of little remaining medical relevance. However, given 400,000 HCV-related deaths annually important challenges remain, including identifying those who are infected, providing access to treatment and reducing its costs. Moreover, HCV infection rarely induces sterilizing immunity, and those who have been cured with DAAs remain at risk for reinfection. Thus, it is very unlikely that global eradication and elimination of the cancer risk associated with HCV infection can be achieved without a vaccine, yet research in that direction receives little attention. Further, over the past two decades HCV research has spearheaded numerous fundamental discoveries in the fields of molecular and cell biology, immunology and microbiology. It will continue to do so, gi...Continue Reading

Citations

Aug 14, 2018·The Journal of Infectious Diseases·Rodrigo Velázquez-MoctezumaJannick Prentoe
Jan 5, 2019·Reviews in Medical Virology·Ramisha KhanMuhammad Idrees
Jan 10, 2019·Viruses·Nathalie Alazard-DanyFrançois-Loïc Cosset
Jan 17, 2019·Non-coding RNA·Nkerorema Djodji DamasTroels K H Scheel
Mar 17, 2019·International Journal of Molecular Sciences·Gesche K GerresheimMichael Niepmann
Oct 4, 2018·Current Computer-aided Drug Design·Sherly Kurnia DewiVivitri Dewi Prasasty
May 11, 2019·The Journal of Infectious Diseases·Stephen M Laidlaw, Lynn B Dustin
Aug 9, 2019·Expert Review of Gastroenterology & Hepatology·C Nelson HayesKazuaki Chayama
Aug 9, 2019·PLoS Pathogens·Luhua Qiao, Guangxiang George Luo
Nov 8, 2019·The Journal of Clinical Investigation·Maike SmitsTobias Boettler
Sep 19, 2019·Médecine sciences : M/S·Marion ChanutSolène Denolly
Apr 2, 2020·International Journal of Molecular Sciences·Michael Niepmann, Gesche K Gerresheim
Jul 12, 2019·Journal of Virology·Raphael WolfisbergTroels K H Scheel
May 28, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Elodie BeaumontPhilippe Roingeard
Jul 23, 2020·PloS One·Huong T L TranDarius Moradpour
Jan 24, 2019·Nature Communications·Xiaodong ZhuangJane A McKeating
Sep 19, 2019·Oxidative Medicine and Cellular Longevity·Zhenzhen ZhangYi-Ping Li
Oct 18, 2019·Therapeutic Advances in Vaccines and Immunotherapy·Georgia KoutsoumpliToos Daemen
Jul 25, 2020·Nature Reviews. Gastroenterology & Hepatology·Andrea L CoxFabien Zoulim
Jun 13, 2018·Frontiers in Immunology·Johnathan D Guest, Brian G Pierce
Mar 7, 2020·Clinical Liver Disease·Harvey J AlterRobert H Purcell
Apr 16, 2020·Viruses·François-Loïc CossetSolène Denolly
Sep 26, 2020·International Journal of Molecular Sciences·Gesche K GerresheimMichael Niepmann
May 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jannick PrentoeJens Bukh
Aug 7, 2019·BMC Infectious Diseases·Jean Damascene MakuzaSabin Nsanzimana
Jul 14, 2018·Frontiers in Immunology·Naglaa H Shoukry
Mar 28, 2020·Patient Related Outcome Measures·Jayne Smith-PalmerKristien Bonroy
Oct 30, 2020·Journal of Biomolecular Structure & Dynamics·Ismail HdoufaneDriss Cherqaoui
Dec 3, 2020·Military Medical Research·Wei HuFu-Sheng Wang
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Johnathan D GuestThomas R Fuerst
Feb 11, 2021·The New England Journal of Medicine·Kimberly PageAndrea L Cox

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