Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring

PloS One
Signe M Lundsgaard-NielsenAnders Weber

Abstract

One of the most ambitious endeavors in the field of diabetes technology is non-invasive glucose sensing. In the past decades, a number of different technologies have been assessed, but none of these have found its entry into general clinical use. We report on the development of a table-top confocal Raman spectrometer that was used in the home of patients with diabetes and operated for extended periods of time unsupervised and without recalibration. The system is based on measurement of glucose levels at a 'critical depth' in the skin, specifically in the interstitial fluid located below the stratum corneum but above the underlying adipose tissue layer. The region chosen for routine glucose measurements was the base of the thumb (the thenar). In a small clinical study, 35 patients with diabetes analyzed their interstitial fluid glucose for a period of 60 days using the new critical-depth Raman (CD-Raman) method and levels were correlated to reference capillary blood glucose values using a standard finger-stick and test strip product. The calibration of the CD-Raman system was stable for > 10 days. Measurement performance for glucose levels present at, or below, a depth of ~250μm below the skin surface was comparable to that repo...Continue Reading

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Citations

Feb 29, 2020·Sensors·Maryamsadat Shokrekhodaei, Stella Quinones
Aug 14, 2020·Journal of Diabetes Science and Technology·Stefan PleusGuido Freckmann
Feb 12, 2020·Science Advances·Jeon Woong KangPeter T C So
Dec 29, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Guido FreckmannRobbert J Slingerland
Mar 8, 2021·Biosensors & Bioelectronics·Maciej S WróbelJanusz Smulko
Mar 12, 2021·Food Chemistry·N González-ViverosH H Cerecedo-Núñez

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Clinical Trials Mentioned

NCT03368209

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