PMID: 3746922Jul 1, 1986Paper

Critical evaluation of isometric indexes of relaxation in rat and cat papillary muscles and toad ventricular strips

Journal of Molecular and Cellular Cardiology
A MattiazziH E Cingolani

Abstract

The effects of increasing calcium concentration and isoproterenol on myocardial relaxation were compared in cat and rat papillary muscles and toad ventricular strips. Isoproterenol effects were studied at equivalent positions of the calcium contractility response curve in the three species: at the plateau and at 25% and 50% of maximum. Calcium concentration was increased from the 25% point to the plateau of the calcium contractility curve for each species. Contractility was characterized by maximal velocity of tension development (+T). To study the relaxation phase, the following parameters were measured: maximal velocity of relaxation, (-T), the relationship between +T and -T (+T/-T), time to peak tension (TTP), time to half relaxation (t 1/2), relaxation time (Rt), total twitch duration (Tt) and the time constant of isometric tension decline from the time of -T (Tau). In rat muscles, t 1/2, Rt and Tt at all calcium levels, and Tau and +T/-T at the 50% and 100% of the calcium contractility curve, behaved as 'lusitropic': they significantly decreased with isoproterenol and not with calcium. Similar results were obtained in cat muscles except that at the 50% point of the calcium contractility curve, +T/-T was not significantly d...Continue Reading

Citations

Jul 1, 1996·Molecular and Cellular Biochemistry·S M MoscaH E Cingolani
Dec 21, 1994·Molecular and Cellular Biochemistry·M V PetroffA Mattiazzi
Sep 1, 1994·Journal of Pharmacological and Toxicological Methods·L VittoneH Cingolani
Nov 1, 1996·Journal of Pharmacological and Toxicological Methods·M W LutzT Rimele
Mar 15, 2000·Journal of Pharmacological and Toxicological Methods·S Baudet, J Noireaud
Sep 28, 1999·British Journal of Pharmacology·J M BrusqJ Kirilovsky
Nov 16, 2001·Journal of Molecular and Cellular Cardiology·M A SalasA Mattiazzi
Jan 22, 2009·British Journal of Pharmacology·J H De MaeyerR A Lefebvre
Aug 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·R NapolitanoA Mattiazzi
Nov 1, 1987·Basic Research in Cardiology·C Mundiña de WeilenmannA Mattiazzi
Aug 5, 1998·The American Journal of Physiology·S P BellM M LeWinter
Oct 1, 1996·Journal of Applied Physiology·G E TaffetC A Tate
May 24, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M SaidA Mattiazzi
Feb 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Espen W RemmeOtto A Smiseth
Aug 11, 2004·Journal of Theoretical Biology·Leonid B KatsnelsonVladimir S Markhasin

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