Critical evaluation of the American Joint Committee on Cancer TNM nodal staging system in patients with lymph node-positive disease after radical cystectomy

European Urology
H Max BruinsEila C Skinner

Abstract

The current 7th edition of the American Joint Committee on Cancer TNM staging system for bladder cancer stages lymph node (LN)-positive disease based on LN location rather than LN size. In addition, common iliac LNs are now considered regional LNs. Whether these changes improve prognostication for node-positive patients, however, remains unclear. To investigate whether the 7th edition of the TNM nodal staging system provides superior prognostication compared with the 6th edition. Patients between 2002 and 2008 with LN metastases after radical cystectomy combined with extended or superextended LN dissection were included. Patients were staged using both TNM staging systems. Median follow-up was 54 mo. Kaplan-Meier curves were used to estimate overall survival (OS) and recurrence-free survival (RFS). Log-rank tests and Cox proportional hazard regression models were used to test associations of pathologic variables with OS and RFS. Included were 146 patients with LN metastases of whom 131 patients underwent superextended LN dissection and 15 patients underwent extended LN dissection. Although in the 7th TNM edition many patients moved from the N2 category to the N3 category, RFS did not significantly differ within the nodal subgro...Continue Reading

References

Jul 13, 2002·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
Dec 23, 2004·The American Journal of Surgical Pathology·Achim FleischmannUrs E Studer
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liang ChengAntonio Lopez-Beltran
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton

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Citations

Feb 22, 2013·Current Opinion in Oncology·Matthew J ResnickPeter E Clark
Feb 13, 2015·Future Oncology·Jose A PedrosaLiang Cheng
Jan 15, 2015·Japanese Journal of Clinical Oncology·Hiroshi Kitamura, Yoshiyuki Kakehi
Sep 23, 2014·Urologic Oncology·Brian HuSiamak Daneshmand
Oct 19, 2013·Expert Review of Anticancer Therapy·Jose A PedrosaLiang Cheng
Jul 16, 2013·Current Opinion in Urology·Kamal S Pohar
Nov 5, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Tohru Nakagawa
May 11, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Cosimo De NunzioAndrea Tubaro

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