PMID: 3917360Jan 1, 1985

Critical evaluation of the role of nutritional support with chemotherapy

Cancer
R T Chlebowski

Abstract

Although weight loss has an adverse impact on cancer patient survival, the ability of caloric provision via total parenteral nutrition (TPN) to favorably influence outcome in chemotherapy-treated populations is not established. In randomized trials, no significant improvement in either response or survival was associated with TPN addition to chemotherapeutic treatment of adult patients with lymphoma, sarcoma, colon cancer, adenocarcinoma and small cell carcinoma of the lung, or testicular carcinoma. In two instances, TPN addition was associated with decreased survival, again raising the concern that caloric support in the absence of effective antitumor therapy might stimulate cancer growth. In any event, the hypothesis that nutritional repletion of a malnourished cancer patient receiving chemotherapy will improve clinical outcome remains to be critically tested, as studies demonstrating sequential improvement in lean body mass have not been reported. Most recently, consideration of potential mechanisms underlying the development of cancer cachexia has led to new strategies for nutritional intervention. For example, hypogonadism or low testosterone levels have been described in male patient populations with advanced cancer and c...Continue Reading

References

May 1, 1979·Cancer·S N Aker
Nov 1, 1979·The American Journal of Clinical Nutrition·J T GoodgameM F Brennan
Jan 1, 1974·Annals of the New York Academy of Sciences·J Gold
Jun 1, 1983·Pharmacological Research Communications·G LelliF Pannuti
Jan 1, 1982·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·B SerrouF B Michel
Jan 8, 1983·British Medical Journal·B GreenwayR Williams
Jan 1, 1980·Medical and Pediatric Oncology·J van EysC Ortiz
Aug 13, 1981·The New England Journal of Medicine·M F Brennan
Jan 1, 1982·Medical and Pediatric Oncology·S S DonaldsonW D DeWys
Jun 1, 1982·The American Journal of Clinical Nutrition·E G de VriesH G de Vries-Hospers
Mar 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·M FreemanM Valdivieso
May 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·E M Copeland
Jul 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·T KishiI Chibata
Jun 15, 1980·Cancer·G P BuzbyE F Rosato
Jan 1, 1954·Advances in Cancer Research·L D FENNINGER, G B MIDER
Feb 1, 1956·The American Journal of Medicine·A R TEREPKA, C WATERHOUSE

Citations

Jun 1, 1991·The Journal of Urology·B MoskovitzD R Levin
Sep 15, 1986·Cancer·S KleinG L Blackburn
Jan 1, 1987·Nutrition and Cancer·J Gold
Feb 1, 1993·The Annals of Pharmacotherapy·M L ChristensenM C Storm
Jan 1, 1987·Nutrition and Cancer·R S HurleyJ A Neidhart
Jan 1, 1985·Cancer·F A Hoffman

Related Concepts

Antineoplastic Agents
Cachexia
Clinical Trials
Combined Modality Therapy
Glucose, (beta-D)-Isomer
Primary Hypogonadism
Malignant Neoplasms
Malnutrition
Dietary Requirements
Parenteral Nutrition

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

JPEN. Journal of Parenteral and Enteral Nutrition
D B PearlstoneM E Burt
Hematology/oncology Clinics of North America
M K ChenE M Copeland
JPEN. Journal of Parenteral and Enteral Nutrition
K A Kern, J A Norton
JPEN. Journal of Parenteral and Enteral Nutrition
Kathleen MulliganMorris Schambelan
Anti-cancer Drugs
M J Tisdale
© 2021 Meta ULC. All rights reserved