Critical flicker fusion frequency in demyelinating and ischemic optic neuropathies

International Ophthalmology
Matthew T YoungScott R Haines

Abstract

Critical flicker fusion (CFF) frequency is a well-studied test for evaluating demyelinating optic neuritis (ON). Its use in evaluating other optic neuropathies is not well established. The purpose of this study was to compare CFF in ON and non-arteritic anterior ischemic optic neuropathy (NAION). We performed a retrospective review to compare multiple variables for eyes with ON or NAION using two-sided T tests and Chi-square tests. A multivariate linear regression was performed for the dependent variable CFF. A receiver operating characteristic (ROC) curve was used to define a CFF threshold for distinguishing these entities. Unaffected eyes had an average CFF value of 31.5 Hz. CFF values for ON (20.7 Hz ± 7.36) and NAION (24.3 Hz ± 9.03) were not significantly different from each other (P = 0.06). However, the CFF for ON, 18.27 Hz ± 9.29, was significantly lower than for NAION, 23.92 Hz ± 7.02, P = 0.02 when limiting the comparison to moderate and severe disease. An ROC curve demonstrates that a CFF value of ≤24 Hz is 71% sensitive for ON and that a value >24 Hz is 74% specific for excluding ON. A multivariate linear regression model demonstrated that ON contributed to approximately an 8 Hz decrease in CFF compared to NAION. Pa...Continue Reading

References

Jan 1, 1979·Vision Research·E HartmannH Brettel
Aug 1, 1991·Annals of Neurology·D M Jacobson, K A Olson
Apr 1, 1954·Physiological Reviews·C LANDIS
Feb 1, 1957·A.M.A. Archives of Neurology and Psychiatry·P N MILLER, O A PARSONS
Aug 1, 1961·Journal of Neurology, Neurosurgery, and Psychiatry·A F TITCOMBE, R G WILLISON
Aug 1, 1947·Journal of Experimental Psychology·H MISIAK
Jul 1, 2011·Indian Journal of Psychological Medicine·Ajay KhadeAvinash Turankar
Feb 15, 2014·JAMA Ophthalmology·Scott R Haines, Reid A Longmuir
Aug 2, 2015·Journal of the Neurological Sciences·N RazN Levin
Sep 16, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Catherine MewbornL Stephen Miller
Sep 29, 2015·Metabolic Brain Disease·Marsha Y MorganKarin Weissenborn
Apr 22, 2016·Case Reports in Ophthalmology·Hyera KangHirohiko Kakizaki

❮ Previous
Next ❯

Citations

Dec 18, 2019·Applied Neuropsychology. Child·Sarah E SaintLisa M Renzi-Hammond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved