Jun 12, 2001

Critical illness polyneuropathy: clinical findings and cell culture assay of neurotoxicity assessed by a prospective study

Intensive Care Medicine
A DruschkyB Neundörfer

Abstract

First, to evaluate the role of typical intensive care-related conditions like sepsis, prolonged ventilation, drug effects and metabolic disorders in the pathogenesis of critical illness polyneuropathy (CIP); second, to investigate the possible significance of patient serum neurotoxicity assessed by an in vitro cytotoxicity assay with respect to CIP development. Prospective study. Neurological intensive care unit. Twenty-eight patients who were on mechanical respiratory support for at least 4 days during a 21-month study period. Diagnosis of CIP was established by clinical and electrophysiological examination in 16 (57%) of 28 patients. Patients were investigated on days 4, 8 and 14 of mechanical ventilation. Two of 16 CIP patients had clinical signs of polyneuropathy at initial examination. Factors that correlated significantly with the development of CIP were: the multiple organ failure score on day 8 of ventilation, the total duration of respiratory support, the presence of weaning problems and the manifestation of complicating sepsis and/or lung failure. The in vitro toxicity assay showed serum neurotoxicity in 12 of 16 CIP patients. Electrophysiological investigations yielded false positive results of the toxicity assay in ...Continue Reading

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Mentioned in this Paper

Septicemia
Surface Electromyography
Polyneuropathy
Pathogenic Aspects
Pathogenesis
Cytotoxicity Assay
Lung
Aminoglycosides
Bacteriocidal Agents
Cell Culture Techniques

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