Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients

Intensive Care Medicine
J Garnacho-MonteroM R Moyano-Del-Estad


To determine risk factors and clinical consequences of critical illness polyneuropathy (CIP) evaluated by the impact on duration of mechanical ventilation, length of stay and mortality. Inception cohort study. Intensive care unit of a tertiary hospital. Septic patients with multiple organ dysfunction syndrome requiring mechanical ventilation and without previous history of polyneuropathy. Patients underwent two scheduled electrophysiologic studies (EPS): on the 10th and 21st days after the onset of mechanical ventilation. Eighty-two patients were enrolled, although nine of them were not analyzed. Forty-six of the 73 patients presented CIP on the first EPS and 4 other subjects were diagnosed with CIP on the second evaluation. The APACHE II scores of patients with and without CIP were similar on admission and on the day of the first EPS. However, days of mechanical ventilation [32.3 (21.1) versus 18.5 (5.8); p=0.002], length of ICU and hospital stay in patients discharged alive from the ICU as well as in-hospital mortality were greater in patients with CIP (42/50, 84% versus 13/23, 56.5%; p=0.01). After multivariate analysis, independent risk factors were hyperosmolality [odds ratio (OR) 4.8; 95% confidence intervals (95% CI) 1.0...Continue Reading


Oct 30, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A GrimmH Axer
Jul 20, 2007·Intensive Care Medicine·Robert D StevensDale M Needham
Oct 24, 2008·Intensive Care Medicine·Catherine L HoughLeonard D Hudson
Sep 28, 2010·Intensive Care Medicine·Lise PiquilloudDidier Tassaux
Aug 19, 2011·Intensive Care Medicine·Karen MaesGhislaine Gayan-Ramirez
Nov 4, 2011·Intensive Care Medicine·Daniel TuchschererLukas Brander
Mar 26, 2005·Journal of Neurology·J BednaríkI Cundrle
Nov 15, 2007·Journal of Neurology·Clarissa Crone, Christian Krarup
Feb 20, 2008·Journal of Neurology·B MohammadiJ Bufler
Nov 5, 2013·Enfermería intensiva·G Via ClaveroA Díaz-Prieto-Huidobro
Jun 20, 2003·Lancet·Jean-Louis Vincent
Apr 17, 2008·European Journal of Anaesthesiology. Supplement·I Shehu, E Peli
Jul 7, 2009·Nature Reviews. Neurology·Wolfgang ZinkStefan Schwab
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Garnacho-MonteroJ Madrazo-Osuna
Oct 19, 2002·Current Opinion in Critical Care·Walther N K A van Mook, Riquette P M G Hulsewé-Evers
Mar 27, 2003·Current Opinion in Critical Care·Andrew MacDuff, Ian S Grant
May 29, 2004·Current Opinion in Critical Care·Bernard de JongheHervé Outin
Jan 7, 2004·Critical Care Medicine·Ross Freebairn
Feb 9, 2005·Critical Care Medicine·Fernando Frutos-Vivar, Andrés Esteban
Sep 15, 2007·Critical Care Medicine·Bernard de JongheGroupe de Réflexion et d'Etude des Neuromyopathies en Réanimation
Mar 11, 2005·Current Opinion in Critical Care·Nicola LatronicoMarco Botteri
Jul 15, 2005·Current Opinion in Critical Care·Nicola LatronicoElisa Seghelini
Jan 26, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Stephen WilliamsMonique M Ryan
Aug 19, 2009·Critical Care Medicine·J Garnacho-Montero, Rosario Amaya Villar
Sep 23, 2009·Critical Care Medicine·Tarek SharsharGroupe de Réflexion et d'Etude des Neuromyopathies En Réanimation
Feb 6, 2010·Critical Care Medicine·Bernard de JongheHervé Outin
Feb 6, 2010·Critical Care Medicine·Robert D StevensTarek Sharshar
Feb 6, 2010·Critical Care Medicine·Greet HermansGreet Van den Berghe
Feb 6, 2010·Critical Care Medicine·Jean-Louis Vincent, Michelle Norrenberg
Jan 6, 2010·Critical Care Medicine·Richard D Griffiths, Jesse B Hall
Mar 1, 2012·Journal of Clinical Neuromuscular Disease·David Lacomis
Dec 14, 2011·Current Opinion in Critical Care·Terence Ip, Sangeeta Mehta
Jan 17, 2012·Journal of Pediatric Hematology/oncology·Koichi HirabayashiKenichi Koike
Oct 14, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L H Visser
Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·Steven DeemJ Randall Curtis
Dec 2, 2006·American Journal of Respiratory and Critical Care Medicine·Greet HermansGreet Van den Berghe
May 31, 2008·American Journal of Respiratory and Critical Care Medicine·Naeem A AliMidwest Critical Care Consortium
May 3, 2012·American Journal of Respiratory and Critical Care Medicine·Zudin PuthuchearyNicholas Hart
Jun 27, 2003·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Martin J Tobin
Oct 16, 2012·Annals of Intensive Care·David PriceNicholas Stollenwerk
Feb 1, 2011·Critical Care : the Official Journal of the Critical Care Forum·Catherine L HoughEllen S Caldwell

Related Concepts

Likelihood Functions
Parenteral Route of Drug Administration
Polyneuropathy, Critical Illness
Intensive Care Unit
Multiple Organ Failure
Ventilation, Function (Observable Entity)
Cardiac Electrophysiologic Stimulation and Recording Study

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.