Critical Illness Secondary to Synthetic Cannabinoid Ingestion

JAMA Network Open
Ismini KourouniJoseph P Mathew

Abstract

Synthetic cannabinoids (SCs), commonly known as K2, spice, or fake weed, are cheap, artificially manufactured recreational drugs that have emerged as a major public health threat in various regions of the US. To describe the clinical manifestations of SC intoxication. This case series assessed adults admitted to the intensive care unit from 2014 to 2016 with acute life-threatening complications of SC use. Data analysis was completed in October 2016. Use of SCs such as K2, spice, or other synthetic versions of cannabinoids. Data collected included patient demographic data, medical history, presenting symptoms, physical findings, laboratory and imaging data, and intensive care unit and hospital course. Thirty patients (mean age, 41 years [range, 21-59 years]; 24 men [80%]) with SC ingestion were admitted to the intensive care unit over a 2-year period. Thirteen patients were undomiciled. The majority had a history of polysubstance abuse, psychiatric illness, or personality disorder. The admission diagnoses were coma (10 patients [33%]), agitation (10 patients [33%]), and seizure (6 patients [20%]). Eighteen patients (60%) had acute respiratory failure, and tracheal intubation was required in 21 patients (70%) for either airway pr...Continue Reading

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Citations

Mar 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Astrid Coronado-ÁlvarezEric Murillo-Rodríguez
Jul 11, 2021·Advances in Pediatrics·Raymen R Assaf, Kelly D Young

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