Critical importance of in vivo amoxicillin and cefotaxime concentrations for synergy in treatment of experimental Enterococcus faecalis endocarditis.

Antimicrobial Agents and Chemotherapy
O Join-LambertC Carbon

Abstract

The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 microg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.

References

Oct 12, 1990·Journal of Chromatography·F JehlH Monteil
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·U Ganzinger, A Haslberger
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·R D PearsonS W Chapman
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·J L MainardiF W Goldstein

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Citations

Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thuan Le, Arnold S Bayer

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