Critical National Shortage of Cefazolin in Japan: Management Strategies.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Hitoshi HondaAkane Takamatsu

Abstract

The shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a first-line agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.

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Citations

Jun 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ashish Kumar KakkarSamir Malhotra
Jul 27, 2021·Frontiers in Pharmacology·Sundus ShukarCaijun Yang
Aug 23, 2021·International Journal of Pharmaceutics·S V ValiulinG G Dultseva

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