Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses

Emerging Microbes & Infections
Wanbo TaiLanying Du

Abstract

Zika virus (ZIKV) infection remains a serious health threat due to its close association with congenital Zika syndrome (CZS), which includes microcephaly and other severe birth defects. As no vaccines are available for human use, continuous effort is needed to develop effective and safe vaccines to prevent ZIKV infection. In this study, we constructed three recombinant proteins comprising, respectively, residues 296-406 (E296-406), 298-409 (E298-409), and 301-404 (E301-404) of ZIKV envelope (E) protein domain III (EDIII) fused with a C-terminal Fc of human IgG. Our results demonstrated that E298-409 induced the highest titer of neutralizing antibodies against infection with nine ZIKV strains isolated from different hosts, countries, and time periods, and it maintained long-term anti-ZIKV immunogenicity to induce neutralizing antibodies. Pups born to mice immunized with E298-409 were fully protected against lethal challenge with two epidemic human ZIKV strains, 2015/Honduras (R103451) and 2015/Colombia (FLR). Passive transfer of anti-E298-409 mouse sera protected pups born to naive mice, as well as type I interferon receptor-deficient adult A129 mice, from lethal challenge with human ZIKV strains R103451 and FLR, and this protec...Continue Reading

References

Apr 2, 2016·Science·Devika SirohiRichard J Kuhn
Apr 27, 2016·Lancet·Patrícia BrasilTom Solomon
Jun 25, 2016·Nature Immunology·Wanwisa DejnirattisaiGavin R Screaton
Jun 30, 2016·BMJ : British Medical Journal·Owen Dyer
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Jul 4, 2016·Lancet·Roosecelis Brasil MartinesSherif R Zaki
Jul 30, 2016·Nature Reviews. Drug Discovery·Chris Morrison
Aug 1, 2016·Cell·Haiyan ZhaoDaved H Fremont
Oct 4, 2016·JAMA Neurology·Adriana Suely de Oliveira MeloAmilcar Tanuri
Oct 7, 2016·Science·Dirk P Dittmer
Oct 7, 2016·Science·Kimberly A DowdBarney S Graham
Oct 9, 2016·EBioMedicine·Eun KimAndrea Gambotto
Oct 21, 2016·Archives of Pathology & Laboratory Medicine·Carey L Medin, Alan L Rothman
Jan 17, 2017·Clinical & Translational Immunology·Lauren M PaulSharon Isern
Feb 23, 2017·Cell·Justin M RichnerMichael S Diamond
Mar 17, 2017·Nature Communications·S Saif HasanMichael G Rossmann
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jucille do Amaral MenesesLindomar José Pena
Apr 7, 2017·MMWR. Morbidity and Mortality Weekly Report·Megan R ReynoldsU.S. Zika Pregnancy Registry Collaboration
Apr 7, 2017·JAMA : the Journal of the American Medical Association·Daniel LuceySabrina Sholts
Apr 20, 2017·Frontiers in Microbiology·Irfan A RatherYong-Ha Park
Jun 8, 2017·Nature Communications·Bryan D GriffinGary P Kobinger
Jul 15, 2017·Cell·Justin M RichnerMichael S Diamond
Aug 8, 2017·Expert Review of Vaccines·Lanying DuShibo Jiang
Oct 5, 2017·The New England Journal of Medicine·Pablo TebasJoel N Maslow

Citations

Jun 14, 2019·Journal of Virology·Wanbo TaiLanying Du
Feb 27, 2020·Reviews in Medical Virology·Arianna Mahely Hurtado-MonzónRosa María Del Ángel
Nov 25, 2018·Vaccines·Khairunnisa Abdul GhaffarLaurent Renia
Sep 5, 2019·Pharmaceuticals·Juan-Carlos Saiz
Mar 3, 2020·Frontiers in Immunology·Franciane Mouradian Emidio TeixeiraMaria Notomi Sato
Nov 18, 2018·Viruses·Himanshu GargAnjali Joshi
Apr 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shannon R EssweinPamela J Bjorkman
Oct 18, 2020·Science China. Life Sciences·Moujian GuoYing Wu
Jan 21, 2021·Pathogens·Gabriel Augusto Pires de SouzaLuiz Felipe Leomil Coelho

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Immunogenicity, Vaccine
Metazoa
Antibodies, Viral
IgG2B
Normal Serum Globulin Therapy
Proteins, Recombinant DNA
Corona Virus Membrane Protein E1
Viral Vaccines

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