Jun 1, 1976

Critical opening pressure and reactivity of tail vessels in conscious hypertensive rats

Canadian Journal of Physiology and Pharmacology
A C DarkeP Gaskell


The possible role of increased vascular reactivity in the mechanism of experimental hypertension was studied by measurements of the critical opening pressure (COP) of tail vessels in conscious rats. In hypertension induced by administration of desoxycorticosterone acetate (DOCA) and replacement of the drinking water by 1% NaCl solution (DOCA-NaCl hypertension), and in one-kidney Goldblatt renovascular hypertension, the raised level of blood pressure was associated with an increased COP of the tail vessels when measured both before and after ganglionic blockade. In rats treated with either DOCA alone or 1% NaCl alone there was no significant increase in systolic blood pressure (SBP) or COP relative to the corresponding controls. In all four experimental series intravenous infusion of angiotensin or norepinephrine in conscious ganglion-blocked rats produced dose-dependent increases in SBP and COP. In DOCA-NaCl hypertensive rats but not in renovascular hypertensives, nor in rats treated with DOCA alone or 1% NaCl alone, the increase in COP for a given increment in dose of angiotensin or norepinephrine was significantly greater than in the control rats. It is concluded that in DOCA-NaCl hypertension there is a true increase in the ...Continue Reading

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Mentioned in this Paper

Hypertension, Renovascular
Diastolic Blood Pressure
Regional Blood Flow
Norepinephrine, (+, -)-Isomer
Pulmonary Vascular Resistance
Angiotensin II, Val(5)-
Hypertensive Disease
Ganglionic Blockers

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