Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.

Oncogene
A L Fridman, M A Tainsky

Abstract

Bypassing cellular senescence and becoming immortal is a prerequisite step in the tumorigenic transformation of a cell. It has long been known that loss of a key tumor suppressor gene, such as p53, is necessary, but not sufficient, for spontaneous cellular immortalization. Therefore, there must be additional mutations and/or epigenetic alterations required for immortalization to occur. Early work on these processes included somatic cell genetic studies to estimate the number of senescence genes, and microcell-mediated transfer of chromosomes into immortalized cells to identify putative senescence-inducing genetic loci. These principal studies laid the foundation for the field of senescence/immortalization, but were labor intensive and the results were somewhat limited. The advent of gene expression profiling and bioinformatics analysis greatly facilitated the identification of genes and pathways that regulate cellular senescence/immortalization. In this review, we present the findings of several gene expression profiling studies and supporting functional data, where available. We identified universal genes regulating senescence/immortalization and found that the key regulator genes represented six pathways: the cell cycle pRB/p...Continue Reading

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S GoldsteinR C Baxter
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·O M Pereira-Smith, J R Smith
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Röhme
Dec 8, 1995·The Journal of Biological Chemistry·T RussoE Appella
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K SwisshelmR Sager
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·Q ChenB N Ames
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·Q Chen, B N Ames
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K SandhuR S Athwal
Jul 1, 1993·Physiological Reviews·V J Cristofalo, R J Pignolo
Jan 1, 1996·Experimental Gerontology·B Lecka-CzernikS Goldstein
Jan 1, 1997·Molecular Carcinogenesis·T TsutsuiJ C Barrett
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M HagenB N Ames
May 1, 1996·Genes, Chromosomes & Cancer·P J VojtaJ C Barrett
Sep 26, 1997·Nature·K PolyakB Vogelstein
May 23, 1998·American Journal of Human Genetics·N G BérubéO M Pereira-Smith
Nov 26, 1998·Experimental Cell Research·K K JhaH L Ozer
Mar 13, 1999·The Journal of Biological Chemistry·A C LeeT Finkel
Oct 6, 1999·Current Biology : CB·D N SheltonW D Funk
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
Jun 1, 2000·Experimental Gerontology·F Bringold, M Serrano
Nov 7, 2000·Current Opinion in Cell Biology·A S LundbergR A Weinberg
Mar 16, 2001·Experimental Gerontology·T SuzukiD Ayusawa

❮ Previous
Next ❯

Citations

Feb 22, 2012·Molecular Neurobiology·Georg AuburgerMarina Jendrach
Jul 3, 2013·Journal of Cardiovascular Translational Research·Rossella MenghiniMassimo Federici
Jun 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Magdalena DabrowskaWojciech Rode
Sep 8, 2009·Expert Reviews in Molecular Medicine·Richard G A FaragherElizabeth L Ostler
Nov 5, 2011·Cell Death and Differentiation·R FaraonioF Cimino
Aug 12, 2009·Cell Research·Francesco P FiorentinoAntonio Giordano
Nov 26, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Vega García-EscuderoFilip Lim
Jun 19, 2013·Nature Cell Biology·Juan Carlos AcostaJesús Gil
Feb 8, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jaromír MikešPeter Fedoročko
Jan 5, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marisa GariglioSanto Landolfo
Apr 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kevin P Kotredes, Ana M Gamero
Nov 6, 2009·Carcinogenesis·Roger R Reddel
Nov 13, 2012·Nucleic Acids Research·Stella TommasiAhmad Besaratinia
Sep 14, 2011·International Journal of Cell Biology·Stephen P HigginsPaul J Higgins
Feb 14, 2014·Nature·Pedro Sousa-VictorPura Muñoz-Cánoves
Feb 1, 2014·Cell Death & Disease·R MenghiniM Federici
Feb 9, 2016·Neuroscience·S KálmánK Mirnics
Aug 21, 2014·Genes·Lorna W Harries
Sep 4, 2015·Biogerontology·Llilians Calvo GonzalezFrancis Rodier
Apr 16, 2013·Immunobiology·Jialu YouParveen Yaqoob
Oct 25, 2011·Seminars in Cancer Biology·Soyoung LeeMaurice Reimann
May 20, 2011·Trends in Genetics : TIG·Myriam Gorospe, Kotb Abdelmohsen
May 17, 2011·Experimental Cell Research·Emily NorthrupNils-Holger Zschemisch
Nov 26, 2010·Clinics in Geriatric Medicine·Neal S Fedarko
Nov 3, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roy SidiEmanuela Felley-Bosco
Sep 4, 2015·Biomolecules & Therapeutics·Moonju Choi, Choongho Lee
Mar 3, 2010·Cancer Genetics and Cytogenetics·Karel SoucekAlois Kozubík
Jul 21, 2009·Neurochemistry International·Jinghua WangHulun Li
May 12, 2009·Seminars in Cancer Biology·Wolfgang A Schulz, Michèle J Hoffmann
Mar 29, 2014·Scientific Reports·Magali OlivierJiri Zavadil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

© 2022 Meta ULC. All rights reserved