PMID: 7526290Jul 4, 1994Paper

Critical period for degradation of adult rat retinal ganglion cells and their regeneration capability after axotomy

Neuroscience Letters
M Takano, H Horie

Abstract

The optic nerve (ON) in adult rats was transected intraorbitally followed by retrograde labelling of retinal ganglion cells (RGCs) with fluorescence dye (DiI). A two phase reduction of axotomized RGCs was represented in the retina until 15 days after ON transection. The critical period of RGC loss is around 7 days after axotomy. In this period, the capability of neurite regeneration from RGCs in culture was strongly intensified by ON transection. These findings indicate that the 7th day after axotomy is important for both RGC survival and regeneration.

Citations

Mar 23, 2004·Molecular and Cellular Neurosciences·Zelda H CheungKwok-Fai So
Dec 2, 1999·Neuroscience Letters·M TakanoY Ishikawa
Aug 5, 2000·Progress in Retinal and Eye Research·P Heiduschka, S Thanos
Nov 16, 2002·Progress in Retinal and Eye Research·Masami Watanabe, Yutaka Fukuda
Mar 17, 2009·The British Journal of Ophthalmology·D EllenbergD T Azar
Jun 7, 2012·Current Eye Research·Hua YanLinlin Zhang
Jul 17, 1998·Vision Research·K F So, H K Yip
Aug 21, 2002·Current Eye Research·Toru NakazawaMakoto Tamai
Feb 10, 1998·The Journal of Comparative Neurology·M ShibayamaA Tessler

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