Critical period regulation

Annual Review of Neuroscience
Takao K Hensch

Abstract

Neuronal circuits are shaped by experience during critical periods of early postnatal life. The ability to control the timing, duration, and closure of these heightened levels of brain plasticity has recently become experimentally accessible, especially in the developing visual system. This review summarizes our current understanding of known critical periods across several systems and species. It delineates a number of emerging principles: functional competition between inputs, role for electrical activity, structural consolidation, regulation by experience (not simply age), special role for inhibition in the CNS, potent influence of attention and motivation, unique timing and duration, as well as use of distinct molecular mechanisms across brain regions and the potential for reactivation in adulthood. A deeper understanding of critical periods will open new avenues to "nurture the brain"-from international efforts to link brain science and education to improving recovery from injury and devising new strategies for therapy and lifelong learning.

References

Nov 10, 1978·Science·M Constantine-Paton, M I Law
Jun 22, 1991·Proceedings. Biological Sciences·M Farrant, S G Cull-Candy
Feb 22, 1991·Brain Research. Developmental Brain Research·G D Mower
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Karni, D Sagi
Nov 30, 1990·Science·P BrennanE B Keverne
May 1, 1989·Brain Research. Developmental Brain Research·J A MaruniakM B Williams
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Alvarez-BuyllaF Nottebohm
Sep 1, 1987·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·H Scheich
Jun 1, 1985·Cellular and Molecular Neurobiology·W J Thompson
Feb 1, 1970·The Journal of Physiology·P B Dews, T N Wiesel
Jan 1, 1970·Developmental Psychobiology·D Jouvet-MounierD Lacote
Jul 1, 1995·Neurobiology of Learning and Memory·E Wallhäusser-FrankeT J DeVoogd
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·M YokoiS Nakanishi
Sep 16, 1994·Brain Research. Developmental Brain Research·J A del RíoE Soriano
Feb 3, 1995·Science·G SchlaugH Steinmetz
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·Q GuM S Cynader
Jun 18, 1993·Science·A Antonini, M P Stryker
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·K FoxD D O'Leary

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Next ❯

Citations

Jul 3, 2013·Cellular and Molecular Life Sciences : CMLS·Kouichi Hashimoto, Masanobu Kano
Aug 1, 2008·Experimental Brain Research·Maria SpolidoroLamberto Maffei
Aug 4, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Tristram D Wyatt
Sep 30, 2010·Journal of the Association for Research in Otolaryngology : JARO·Samuele Carcagno, Christopher J Plack
Jul 14, 2010·Journal of Abnormal Child Psychology·Ayelet Ben-SassonMargaret J Briggs-Gowan
Nov 15, 2008·Neuropsychology Review·Molly HeltDeborah Fein
Aug 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yingchun ZhouXuxia Yi
Feb 23, 2013·Behavioural Brain Research·Pierre Lavenex, Pamela Banta Lavenex
Jun 7, 2005·General and Comparative Endocrinology·Susan B Udin
Jan 31, 2007·European Journal of Anaesthesiology·E GasconL Vutskits
Dec 8, 2005·Visual Neuroscience·Jianhua CangMichael P Stryker
Oct 6, 2006·Visual Neuroscience·Khaleel A Razak, Sarah L Pallas
Dec 19, 2009·Cell Death and Differentiation·L BaroncelliL Maffei
Jun 8, 2013·Nature Medicine·Richard DelormeThomas Bourgeron
Aug 2, 2011·Nature Neuroscience·Tania Rinaldi BarkatTakao K Hensch
Mar 27, 2013·Nature Reviews. Endocrinology·Lily NgDouglas Forrest
Nov 2, 2005·Nature Reviews. Neuroscience·Takao K Hensch
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Judith L Rapoport, Nitin Gogtay
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E David Leonardo, Rene Hen
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mathieu LetellierAnn M Lohof
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·William P FiferPeter D Balsam
Aug 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Friso PostmaPatrick O Kanold
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kouichi HashimotoMasanobu Kano
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stefan VolkensteinStefan Heller
Oct 24, 2009·Journal of Neural Engineering·James B FallonRobert K Shepherd
Apr 24, 2008·British Journal of Anaesthesia·S M Walker
Nov 12, 2002·British Dental Journal·C A Yeung
Jul 26, 2011·Brain : a Journal of Neurology·Vicki AndersonAmanda Wood
Nov 22, 2011·Brain : a Journal of Neurology·Simon BeggsSuellen M Walker
May 1, 2012·Integrative and Comparative Biology·Emilie C Snell-Rood
Jul 31, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Horace MassaLaszlo Vutskits
May 7, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Steven M Barlow
Apr 17, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Steven M Barlow
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irin C Maier, Martin E Schwab
Feb 27, 2010·Science·Derek G SouthwellSunil P Gandhi
Nov 13, 2010·Science·Hirofumi MorishitaTakao K Hensch
Nov 27, 2010·Science·Michael J Higley, Stephen M Strittmatter
Sep 16, 2004·Science's STKE : Signal Transduction Knowledge Environment·Bartlett W Mel, Jackie Schiller
Mar 30, 2010·Annual Review of Neuroscience·C ShilyanskyA J Silva
Mar 6, 2010·Annual Review of Neuroscience·Patrick O Kanold, Heiko J Luhmann
Jul 19, 2005·Annual Review of Neuroscience·Liqun Luo, Dennis D M O'Leary

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BETA
transgenic
cochlear implants

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