Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics

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Suresh Kumar PoovathingalJames R Heath

Abstract

A kinetic, single-cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single-cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first-order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.

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Citations

Jul 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Swetha VasudevanNataly Kravchenko-Balasha
Feb 12, 2021·Expert Review of Proteomics·Vivian Weiwen XueWilliam Chi Cho

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