Critical prevalence of antibodies minimizing vaccination costs for hepatitis A, hepatitis B, varicella, measles and tetanus in adults and adolescents in Catalonia, Spain

Vaccine
Pedro Plans-Rubió

Abstract

The prevalence of seropositive individuals that makes costs of vaccinating all individuals equal to that for screening and vaccination of susceptible individuals is defined as the critical prevalence of antibodies (p*). Screening and vaccination is more efficient when the prevalence of seropositive individuals (p) in the population is higher than p*. In this study, the formula to obtain p* was derived from the cost-effectiveness equations, showing that it depends on screening and vaccination costs, programme compliance, screening test performance, vaccine efficacy and disease costs. The formula was used to determine the least costly vaccination strategy for hepatitis A and B, varicella, measles and tetanus in adults and adolescents in Catalonia. The least costly vaccination strategy was vaccination without screening (since p was lower than p*) for hepatitis B, measles and tetanus in adults and adolescents (5-14 years) and for hepatitis A in individuals aged 5-24 years, and screening and vaccination (since p was higher than p*) for varicella in adults and adolescents and for hepatitis A in adults aged >24 years. Vaccination strategies based on the critical prevalence of antibodies could maximize the immunity level in the communi...Continue Reading

Citations

Nov 16, 2007·Medical Microbiology and Immunology·Lluís SallerasAntoni Plasència
Feb 11, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P PlansL Cabero
Apr 20, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Pedro Plans
Jul 1, 2009·Tropical Medicine & International Health : TM & IH·Bradley C FetzerCharles Mwansambo
Jan 14, 2020·The Pediatric Infectious Disease Journal·Olivia FahrniNoémie Wagner
Dec 30, 2014·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson, Cassie L Odahowski

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