Critical protective role of mast cells in a model of acute septic peritonitis

Nature
B EchtenacherL Hültner

Abstract

Mast cells play a detrimental role in IgE-dependent allergic reactions. In contrast, a protective function for mast cells has been proposed on the basis of some worm infection models. No reports exist on the in vivo significance of these cells in bacterial infections. Here we use congenitally mast-cell-deficient W/Wv mice and normal +/+ littermates to analyse the role of mast cells in a model of acute septic peritonitis (caecum ligation and puncture (CLP)). Following CLP, W/Wv mice showed a significantly increased mortality compared to +/+ mice. The selective reconstitution of W/Wv mice with cultured +/+ mast cells substantially protected them from the lethal effects of CLP, whereas an anti-tumor-necrosis-factor (TNF) antibody injected immediately after CLP completely suppressed this protection. Our results reveal a previously unrecognized protective role of mast cells and mast-cell-derived TNF in acute bacterial peritonitis.

References

Sep 1, 1992·European Journal of Immunology·B F RamosB A Jakschik
Dec 1, 1990·Immunology Today·J R GordonS J Galli
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L Rothstein, H Schreiber
Oct 24, 1986·Science·K J TraceyJ D Albert
Apr 1, 1994·The Journal of Clinical Investigation·R MalaviyaS N Abraham
Jan 1, 1994·Advances in Experimental Medicine and Biology·B K Wershil, S J Galli
Jul 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K L McCleanG K Harding
Feb 1, 1994·Current Opinion in Immunology·L B Schwartz
Jan 28, 1993·The New England Journal of Medicine·S J Galli

❮ Previous
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Citations

Jan 6, 1999·The Journal of Pathology·S ZhangW R Roche
Mar 26, 2005·Archives of Pharmacal Research·Eunkyung LeeHyeun Wook Chang
Jun 4, 2002·International Journal of Hematology·Tatsutoshi Nakahata, Hano Toru
Jun 4, 2002·International Journal of Hematology·Stephen J GalliMindy Tsai
May 27, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Naoki ImajoMasaaki Akagi
Jul 14, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jaciel Medina-TamayoClaudia González-Espinosa
Nov 10, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Krisztina V VukmanSandra M O'Neill
Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
Sep 20, 2008·Journal of Clinical Immunology·Melissa A BrownAlison Christy
Nov 1, 2007·Transgenic Research·Julia ScholtenAxel Roers
Jul 30, 2009·Clinical Reviews in Allergy & Immunology·H David PettigrewM Eric Gershwin
Mar 27, 2004·European Journal of Pharmacology·Ming-Yuan JianKeishi Kubo
May 24, 2003·Biochemical and Biophysical Research Communications·Hiroshi Ohtsu, Takehiko Watanabe
Dec 5, 2002·International Journal for Parasitology·A A M Coelho-CasteloV Rodrigues
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·C O Bingham, K F Austen
May 30, 2001·Leukemia Research·K F Austen, J A Boyce
Jul 14, 2001·Molecular Immunology·M Boes
Sep 10, 2002·Molecular Immunology·Dana BaramRonit Sagi-Eisenberg
Nov 1, 1996·Trends in Neurosciences·R Levi-MontalciniA Leon
May 1, 1997·Immunology Today·S Mécheri, B David
Aug 30, 2000·International Journal of Immunopharmacology·A Zussman, R Sagi-Eisenberg
Apr 21, 2001·FEMS Microbiology Letters·J S Shin, S N Abraham
Oct 1, 1996·Research in Immunology·D N MännelB Echtenacher
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Joshua A Boyce
Dec 5, 2000·Current Opinion in Immunology·J WedemeyerS J Galli
Nov 5, 2002·Current Opinion in Immunology·Michaela Robbie-Ryan, MelissaA Brown
Nov 5, 2002·Current Opinion in Immunology·Howard R Katz
Dec 1, 1996·Current Opinion in Immunology·M A Beaven, R A Baumgartner
Aug 1, 1997·Current Opinion in Immunology·J Reimann, S H Kaufmann
Apr 2, 1998·Current Opinion in Immunology·M C Carroll, A P Prodeus
Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
Aug 19, 1999·Critical Reviews in Oncology/hematology·P Bradding, S T Holgate
Mar 24, 1998·Journal of the American College of Surgeons·B S CainR C McIntyre

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