Critical review and evaluation of the uterotrophic bioassay for the identification of possible estrogen agonists and antagonists: in support of the validation of the OECD uterotrophic protocols for the laboratory rodent. Organisation for Economic Co-operation and Development

Critical Reviews in Toxicology
J William Owens, John Ashby

Abstract

A current issue for regulatory agencies is endocrine-related modes of action such as those mediated by the estrogen, androgen, and thyroid nuclear receptors. At the national and international levels, the consensus recommendation for the assessment of such modes of action is a tiered series of in vitro and in vivo protocols. The tiered framework begins with screens for structural alerts and then moves to rapid, mechanistic in vitro screening assays, and then to in vivo screening bioassays. The objective of these screens is to identify substances that may warrant testing for endocrine-mediated adverse effects. The final framework tier as needed is to test these substances in long-term bioassays for adverse endocrine-mediated reproductive and/or developmental effects. The subject of this review, the rodent uterotrophic bioassay, is intended to be a rapid in vivo screening bioassay for possible estrogen agonists and based on the response of the estrogen-sensitive uterus. The central metric of bioassay is a statistically significant increase in the weight of the uterus after 3 consecutive days of test substance administration. The extensive background literature is summarized in this review on the mode of action underlying the bioas...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C R Lyttle, E R DeSombre
Jan 1, 1992·Reproduction, Fertility, and Development·C A FinnS R Milligan
Jul 1, 1992·American Journal of Respiratory Cell and Molecular Biology·D Sassoon
Sep 24, 1991·Biochimica Et Biophysica Acta·B GarreauE A Nunez
Oct 1, 1988·Journal of Steroid Biochemistry·A E Wakeling, J Bowler
Jun 1, 1988·Journal of Steroid Biochemistry·E R DeSombreA Hughes
Jan 1, 1988·Journal of Steroid Biochemistry·B M MarkaverichJ H Clark
Aug 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E FarmakalidisP A Murphy
Nov 1, 1970·Journal of Agricultural and Food Chemistry·J Bitman, H C Cecil
Dec 12, 1970·Nature·R C Miller, E K Miller
Mar 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Farmakalidis, P A Murphy
Aug 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Farmakalidis, P A Murphy
Dec 1, 1983·Journal of Molecular and Cellular Cardiology·T AbrahamssonL Carlsson
Jul 1, 1980·Alcoholism, Clinical and Experimental Research·O W NeubuergerH H Pratt
Sep 1, 1982·The British Journal of Ophthalmology·M J Roper-Hall
Aug 1, 1980·Food and Cosmetics Toxicology·H M DraneN Saba
Jun 1, 1995·Environmental Health Perspectives·B M MarkaverichR R Gregory
Oct 13, 1994·European Journal of Pharmacology·P C NgG Stone
Nov 1, 1994·The Proceedings of the Nutrition Society·P A MorrisseyP J Sheehy
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·P Van de VeldeG Teutsch
Jan 1, 1993·Health Affairs·S H Long, J Rodgers
Oct 1, 1995·Environmental Health Perspectives·C Teng
Jun 7, 1996·Journal of Toxicology and Environmental Health·K A HostetlerL L Wei
Dec 1, 1996·Chemical Research in Toxicology·C L WallerL E Gray
Jan 1, 1996·Archives of Toxicology·H CertaH M Bolt
Mar 1, 1997·Health Affairs·B H Gray
Mar 1, 1997·Health Affairs·S H ScholleW P Gardner
May 1, 1997·Biology of Reproduction·K L MedlockD M Sheehan

❮ Previous
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Citations

May 12, 2009·Nature Chemical Biology·Megan K DennisEric R Prossnitz
Jun 15, 2007·Journal of Toxicology and Environmental Health. Part a·Margie M Peden-AdamsDeborah E Keil
Jan 25, 2005·Cancer Biotherapy & Radiopharmaceuticals·Zoltán MarcsekAnna Tompa
Sep 3, 2009·Arthritis Research & Therapy·Li BianMattias Magnusson
Sep 2, 2003·Environmental Health Perspectives·William Owens, Herman B W M Koëter
Aug 4, 2004·Environmental Health Perspectives·Jonathan G MoggsGeorge Orphanides
Dec 16, 2004·Environmental Health Perspectives·Jonathan G MoggsGeorge Orphanides
Dec 19, 2007·Environmental Health Perspectives·Stefanie Raymond-WhishCheryl A Dyer
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Geoffrey A WoodRama Khokha
Jun 15, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Si WangToine F H Bovee
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Samantha M Solon-BietStephen J Simpson
May 12, 2012·Reproductive Toxicology·Caitlin J MurphyWilliam J Murdoch
Jul 27, 2007·Vascular Pharmacology·Kathleen M EysterDouglas S Martin
Oct 12, 2013·Journal of Applied Toxicology : JAT·Si WangToine F H Bovee
Jun 27, 2015·Endocrine-related Cancer·Amanda SchechGauri Sabnis
Feb 4, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michael J ChisamoreHilary A Wilkinson
Jul 24, 2015·Science Translational Medicine·Laszlo ProkaiKatalin Prokai-Tatrai
Dec 6, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Si WangToine F H Bovee
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Philip W Harvey, David J Everett
Jan 9, 2004·Biology of Reproduction·William J HendryDaniel M Sheehan
Feb 11, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Christopher J BorgertAbraham Tobia
Feb 12, 2014·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·M Sue Marty, John C O'Connor
Mar 17, 2015·Environmental Health Perspectives·Johanna R Rochester, Ashley L Bolden
Apr 7, 2007·Menopause : the Journal of the North American Menopause Society·Dominik RachońWolfgang Wuttke
Jul 8, 2010·Bioelectromagnetics·Hiroharu YamashitaHirokazu Nagawa
Sep 28, 2017·The American Journal of Chinese Medicine·Ryoiti Kiyama
Sep 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Connie J MarkKathleen M Eyster
Mar 5, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Justin G TeeguardenHugh A Barton

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