Critical role of acrolein in secondary injury following ex vivo spinal cord trauma.

Journal of Neurochemistry
Kristin HamannR Shi

Abstract

The pathophysiology of spinal cord injury (SCI) is characterized by the initial, primary injury followed by secondary injury processes in which oxidative stress is a critical component. Secondary injury processes not only exacerbate pathology at the site of primary injury, but also result in spreading of injuries to the adjacent, otherwise healthy tissue. The lipid peroxidation byproduct acrolein has been implicated as one potential mediator of secondary injury. To further and rigorously elucidate the role of acrolein in secondary injury, a unique ex vivo model is utilized to isolate the detrimental effects of mechanical injury from toxins such as acrolein that are produced endogenously following SCI. We demonstrate that (i) acrolein-Lys adducts are capable of diffusing from compressed tissue to adjacent, otherwise uninjured tissue; (ii) secondary injury by itself produces significant membrane damage and increased superoxide production; and (iii) these injuries are significantly attenuated by the acrolein scavenger hydralazine. Furthermore, hydralazine treatment results in significantly less membrane damage 2 h following compression injury, but not immediately after. These findings support our hypothesis that, following SCI, ac...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Jan 1, 1989·Free Radical Biology & Medicine·G Witz
Aug 1, 1993·Free Radical Biology & Medicine·J D Adams, L K Klaidman
Jan 1, 1995·Reviews of Environmental Contamination and Toxicology·D P Ghilarducci, R S Tjeerdema
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·C S EddlemanG D Bittner
Feb 4, 1999·Journal of Neurochemistry·N Y CalingasanG E Gibson
Jan 20, 2000·Trends in Cardiovascular Medicine·K Uchida
May 24, 2000·Neurochemical Research·N Seiler
Jul 25, 2000·Redox Report : Communications in Free Radical Research·P C BurchamF Fontaine
Aug 31, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J P Kehrer, S S Biswal
Aug 8, 2002·Journal of Neurotrauma·Jen Hill LucasBradford T Stokes
Jan 27, 2004·Journal of Toxicology and Environmental Health. Part a·Hui LiM Firoze Khan
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret M TarpeyMatthew B Grisham
May 8, 2004·The Journal of Pharmacology and Experimental Therapeutics·Lisa M KaminskasPhilip C Burcham
Sep 8, 2004·Organic & Biomolecular Chemistry·Lisa M KaminskasPhilip C Burcham
Jan 27, 2005·Neurochemistry International·Jian Luo, Riyi Shi
Mar 4, 2005·Journal of Cellular Physiology·Jikui ShenPeter A Campochiaro
Jul 16, 2005·Neurochemical Research·Jian LuoRiyi Shi
Jan 19, 2006·Critical Reviews in Toxicology·Peter J O'BrienNandita Shangari
Apr 19, 2006·Journal of Neuroscience Research·Peishan Liu-SnyderRiyi Shi
Jun 20, 2006·Free Radical Biology & Medicine·Changxing ShaoMark A Lovell
Dec 7, 2007·Chemical Research in Toxicology·Lawrence M SayreMark A Smith

❮ Previous
Next ❯

Citations

Mar 23, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D Hall
Oct 13, 2012·Environmental Health Perspectives·Richard M LoPachin, Terrence Gavin
Jul 3, 2013·Oxidative Medicine and Cellular Longevity·Seung Eun Lee, Yong Seek Park
Jul 27, 2010·Journal of Neuroscience Methods·Jie ZhangColin R Green
Aug 2, 2011·Molecular Nutrition & Food Research·Giancarlo AldiniMarina Carini
Aug 9, 2011·Molecular Nutrition & Food Research·Riyi ShiWenjing Sun
Jun 30, 2011·Molecular Nutrition & Food Research·Qin ZhuMingfu Wang
Nov 19, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wei-Guo WangPing-Shan Wang
Apr 2, 2014·BioMed Research International·André Mendes ArentAlcir Luiz Dafre
Apr 29, 2015·Journal of the Neurological Sciences·Andrew MarquisBradley S Duerstock
Feb 21, 2013·Neurochemistry International·Joshua A SmithNaren L Banik
Nov 15, 2011·Biochimica Et Biophysica Acta·Mona Bains, Edward D Hall
Jan 18, 2015·Journal of Bioenergetics and Biomembranes·Edward D HallIndrapal N Singh
Apr 5, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zivar YousefipourMohammad A Newaz
Aug 16, 2013·Nanoscale·Jacqueline Y TylerJi-Xin Cheng
May 17, 2014·Expert Review of Neurotherapeutics·Melissa TullyRiyi Shi
Feb 17, 2017·International Journal of Molecular Medicine·Jing-Xing ZhangJian-Guo Hu
Mar 1, 2011·Journal of Neurochemistry·Yunzhou ShiRiyi Shi
Nov 20, 2015·Journal of Neurophysiology·Rui YanRiyi Shi
Mar 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Ambara R Pradipta, Katsunori Tanaka
Feb 10, 2010·Journal of Proteome Research·Leila Afjehi-SadatGert Lubec

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.